MLLT1

MLLT1
Identifiers
Aliases	MLLT1, ENL, LTG19, YEATS1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, super elongation complex subunit, MLLT1 super elongation complex subunit
External IDs	OMIM: 159556; MGI: 1927238; HomoloGene: 4339; GeneCards: MLLT1; OMA:MLLT1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,279,975 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,242,415 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; placenta; ; right uterine tube; ; right hemisphere of cerebellum; ; myocardium of left ventricle; ; tibialis anterior muscle; ; nucleus accumbens; ; right frontal lobe; ; ventricular zone; ; decidua;
	Top expressed in
	ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; genital tubercle; ; lip; ; superior frontal gyrus; ; primary visual cortex; ; neural tube; ; tail of embryo; ; perirhinal cortex; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription elongation factor complex; nucleus; fibrillar center; nucleoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; negative regulation of protein kinase activity; transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4298
	64144
	ENSG00000130382
	ENSMUSG00000024212
	Q03111
	Q9ERL0
	NM_005934
	NM_022328
	NP_005925
	NP_071723
	Wikidata
View/Edit Human	View/Edit Mouse

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.^[5]

Interactions

MLLT1 has been shown to interact with CBX8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130382 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024212 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
^ García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.

Tkachuk DC, Kohler S, Cleary ML (November 1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624. S2CID 11801536.
Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (December 1994). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12110–4. Bibcode:1994PNAS...9112110T. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593.
Rubnitz JE, Morrissey J, Savage PA, Cleary ML (September 1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. doi:10.1182/blood.V84.6.1747.1747. PMID 8080983.
Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T (October 1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID 8378076.
Lavau C, Luo RT, Du C, Thirman MJ (September 2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (20): 10984–9. Bibcode:2000PNAS...9710984L. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463.
García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
Gué M, Sun JS, Boudier T (January 2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6: 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R (March 2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID 17252016. S2CID 34843802.

External links

MLLT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130382 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024212 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".

[pmid11313972-6] García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.

[1]

[2]

[3]

[4]

[5]

[6]

Interactions

References

Further reading

External links