IRX4

IRX4
Identifiers
Aliases	IRX4, IRXA3, iroquois homeobox 4
External IDs	OMIM: 606199; MGI: 1355275; HomoloGene: 9485; GeneCards: IRX4; OMA:IRX4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,887,236 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,417,727 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; apex of heart; ; skin of leg; ; hair follicle; ; gonad; ; left ventricle; ; minor salivary glands; ; vagina; ; right ventricle; ; epithelium of lactiferous gland;
	Top expressed in
	lip; ; ventricle of the heart; ; atrioventricular canal; ; endocardial cushion; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; atrioventricular valve; ; primordial ventricle; ; upper lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	heart development; regulation of transcription, DNA-templated; establishment of animal organ orientation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	50805
	50916
	ENSG00000113430
	ENSMUSG00000021604
	P78413
	Q9QY61
	NM_016358; NM_001278632; NM_001278633; NM_001278634; NM_001278635
	NM_018885
	NP_001265561; NP_001265562; NP_001265563; NP_001265564; NP_057442
	NP_061373
	Wikidata
View/Edit Human	View/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^[5]^[6]

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: iroquois homeobox 4".
^ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142. S2CID 37046813.
Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777.
Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–820. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113430 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: iroquois homeobox 4".

[pmid10625552-6] Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

[1]

[2]

[3]

[4]

[5]

[6]

Function

References

Further reading