KLF12

KLF12
Identifiers
Aliases	KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	OMIM: 607531; MGI: 1333796; HomoloGene: 21417; GeneCards: KLF12; OMA:KLF12 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	74,133,929 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	100,284,679 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; superficial temporal artery; ; retinal pigment epithelium; ; caput epididymis; ; Brodmann area 23; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; tendon of biceps brachii; ; epithelium of nasopharynx; ; synovial joint;
	Top expressed in
	Rostral migratory stream; ; human fetus; ; tail of embryo; ; genital tubercle; ; retinal pigment epithelium; ; dorsal tegmental nucleus; ; habenula; ; lateral septal nucleus; ; lateral geniculate nucleus; ; medial geniculate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; transcription corepressor activity; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	11278
	16597
	ENSG00000118922
	ENSMUSG00000072294
	Q9Y4X4
	O35738
	NM_007249; NM_016285
	NM_010636
	NP_009180
	NP_034766
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.^[5]^[6]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118922 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072294 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.
^ ^a ^b "Entrez Gene: KLF12 Kruppel-like factor 12".

External links

KLF12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118922 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072294 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10704285-5] Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.

[entrez-6] "Entrez Gene: KLF12 Kruppel-like factor 12".

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KLF12

See also

References

Further reading

External links