Asc-type amino acid transporter 1

SLC7A10
Identifiers
Aliases	SLC7A10, HASC-1, asc-1, ASC1, solute carrier family 7 member 10
External IDs	OMIM: 607959; MGI: 1858261; HomoloGene: 56767; GeneCards: SLC7A10; OMA:SLC7A10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,225,850 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	34,900,539 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; amygdala; ; subcutaneous adipose tissue; ; right frontal lobe; ; anterior cingulate cortex; ; gonad; ; hypothalamus; ; substantia nigra;
	Top expressed in
	lumbar subsegment of spinal cord; ; deep cerebellar nuclei; ; medial vestibular nucleus; ; white adipose tissue; ; Epithelium of choroid plexus; ; central gray substance of midbrain; ; mammillary body; ; dorsal tegmental nucleus; ; subcutaneous adipose tissue; ; inferior colliculi;
	More reference expression data
	n/a
Gene ontology
Molecular function	antiporter activity; L-serine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; transmembrane transporter activity; L-amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	leukocyte migration; neutral amino acid transport; D-alanine transport; amino acid transport; D-serine transport; L-serine transport; transmembrane transport; L-alpha-amino acid transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	56301
	53896
	ENSG00000130876
	ENSMUSG00000030495
	Q9NS82
	P63115
	NM_019849
	NM_017394
	NP_062823
	NP_059090
	Wikidata
View/Edit Human	View/Edit Mouse

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130876 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 10".
^ Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.
^ Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037. S2CID 23904731.

Leclerc D, Wu Q, Ellis JR, et al. (2001). "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?". Mol. Genet. Metab. 73 (4): 333–9. doi:10.1006/mgme.2001.3209. PMID 11509015.
Imielinski M, Baldassano RN, Griffiths A, et al. (2009). "Common variants at five new loci associated with early-onset inflammatory bowel disease". Nat. Genet. 41 (12): 1335–40. doi:10.1038/ng.489. PMC 3267927. PMID 19915574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pineda M, Font M, Bassi MT, et al. (2004). "The amino acid transporter asc-1 is not involved in cystinuria". Kidney Int. 66 (4): 1453–64. doi:10.1111/j.1523-1755.2004.00908.x. hdl:11380/455524. PMID 15458438.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
Bröer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
Xu D, Hemler ME (2005). "Metabolic activation-related CD147-CD98 complex". Mol. Cell. Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130876 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 10".

[pmid10734121-6] Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.

[pmid10863037-7] Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037. S2CID 23904731.

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Asc-type amino acid transporter 1

See also

References

Further reading