SLC13A2

SLC13A2
Identifiers
Aliases	SLC13A2, NADC1, NaCT, NaDC-1, SDCT1, solute carrier family 13 member 2
External IDs	OMIM: 604148; MGI: 1276558; HomoloGene: 2965; GeneCards: SLC13A2; OMA:SLC13A2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,497,781 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,313,043 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; testicle; ; human kidney; ; olfactory zone of nasal mucosa; ; salivary gland; ; minor salivary glands; ; lactiferous duct; ; mucosa of ileum; ; mucosa of transverse colon;
	Top expressed in
	intestinal villus; ; jejunum; ; right kidney; ; left colon; ; proximal tubule; ; ileum; ; human kidney; ; conjunctival fornix; ; morula; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	low-affinity sodium:dicarboxylate symporter activity; symporter activity; transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	ion transport; sodium ion transport; dicarboxylic acid transport; transmembrane transport; anion transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	9058
	20500
	ENSG00000007216
	ENSMUSG00000001095
	Q13183
	Q9ES88
	NM_001145975; NM_001145976; NM_003984; NM_001346683; NM_001346684
	NM_022411
	NP_001139447; NP_001333612; NP_001333613; NP_003975
	NP_071856
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001095 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol. 270 (4 Pt 2): F642–8. doi:10.1152/ajprenal.1996.270.4.F642. PMID 8967342.
^ Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 89–90. doi:10.1159/000015222. PMID 10343111. S2CID 26457719.
^ "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2".

Inoue K, Zhuang L, Ganapathy V (2003). "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function". Biochem. Biophys. Res. Commun. 299 (3): 465–71. doi:10.1016/S0006-291X(02)02669-4. PMID 12445824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bai X, Chen X, Fen Z, et al. (2005). "Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study". Science in China Series C: Life Sciences. 47 (6): 530–9. doi:10.1360/03yc0044. PMID 15620109. S2CID 36487757.
Pajor AM, Randolph KM (2005). "Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter". J. Biol. Chem. 280 (19): 18728–35. doi:10.1074/jbc.M501265200. PMC 1224748. PMID 15774465.
Okamoto N, Aruga S, Matsuzaki S, et al. (2007). "Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls". Int. J. Urol. 14 (4): 344–9. doi:10.1111/j.1442-2042.2007.01554.x. PMID 17470169. S2CID 41274929.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8967342-5] Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol. 270 (4 Pt 2): F642–8. doi:10.1152/ajprenal.1996.270.4.F642. PMID 8967342.

[pmid10343111-6] Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 89–90. doi:10.1159/000015222. PMID 10343111. S2CID 26457719.

[entrez-7] "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2".

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References

Further reading