Sodium bicarbonate cotransporter 3

SLC4A7
Identifiers
Aliases	SLC4A7, NBC2, NBC3, NBCN1, SBC2, SLC4A6, solute carrier family 4 member 7
External IDs	OMIM: 603353; MGI: 2443878; HomoloGene: 2680; GeneCards: SLC4A7; OMA:SLC4A7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	27,484,420 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	14,799,940 bp
RNA expression pattern
	Top expressed in
	oocyte; ; duodenum; ; Achilles tendon; ; jejunal mucosa; ; secondary oocyte; ; lactiferous duct; ; sural nerve; ; frontal pole; ; paraflocculus of cerebellum; ; Brodmann area 23;
	Top expressed in
	duodenum; ; left colon; ; retina; ; olfactory epithelium; ; neural layer of retina; ; medial ganglionic eminence; ; islet of Langerhans; ; uterus; ; soleus muscle; ; spermatid;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	inorganic anion exchanger activity; symporter activity; anion transmembrane transporter activity; sodium:bicarbonate symporter activity; protein binding;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; synapse; stereocilium; basolateral plasma membrane; apical plasma membrane; cytoplasmic vesicle; integral component of plasma membrane;
Biological process	sodium ion transport; anion transport; auditory receptor cell development; ion transport; inorganic anion transport; regulation of intracellular pH; bicarbonate transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9497
	218756
	ENSG00000033867
	ENSMUSG00000021733
	Q9Y6M7
	Q8BTY2
NM_001258379; NM_001258380; NM_003615; NM_001321103; NM_001321104;
	NM_001321105; NM_001321106; NM_001321107; NM_001321108
	NM_001033270
NP_001245308; NP_001245309; NP_001308032; NP_001308033; NP_001308034;
	NP_001308035; NP_001308036; NP_001308037; NP_003606
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000033867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

Ishibashi K, Sasaki S, Marumo F (1998). "Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina". Biochem. Biophys. Res. Commun. 246 (2): 535–8. doi:10.1006/bbrc.1998.8658. PMID 9610397.
Pushkin A, Abuladze N, Lee I, et al. (1999). "Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22". Genomics. 57 (2): 321–2. doi:10.1006/geno.1999.5781. PMID 10198178.
Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. doi:10.1152/ajprenal.1999.277.6.F974. PMID 10600945. S2CID 4457223.
Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
Loiselle FB, Jaschke P, Casey JR (2004). "Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain". Mol. Membr. Biol. 20 (4): 307–17. doi:10.1080/0968768031000122520. PMID 14578046. S2CID 30980041.
Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. S2CID 16522705.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Reiners J, van Wijk E, Märker T, et al. (2006). "Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2". Hum. Mol. Genet. 14 (24): 3933–43. doi:10.1093/hmg/ddi417. PMID 16301216.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000033867 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021733 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

[1]

[2]

[3]

[4]

[5]

Sodium bicarbonate cotransporter 3

See also

References

Further reading