ABCB8

ABCB8
Identifiers
Aliases	ABCB8, EST328128, M-ABC1, MABC1, ATP binding cassette subfamily B member 8, MITOSUR
External IDs	OMIM: 605464; MGI: 1351667; HomoloGene: 5203; GeneCards: ABCB8; OMA:ABCB8 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,047,782 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,615,052 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; apex of heart; ; right adrenal gland; ; right adrenal cortex; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; anterior pituitary; ; left adrenal gland; ; left adrenal cortex; ; left lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; saccule; ; right ventricle; ; otic vesicle; ; muscle of thigh; ; right kidney; ; otic placode; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; ATPase activity; ATP binding; nucleotide binding; ATPase-coupled transmembrane transporter activity;
Cellular component	integral component of membrane; mitochondrial envelope; ATP-binding cassette (ABC) transporter complex; nucleus; nucleolus; mitochondrion; mitochondrial inner membrane; membrane; mitochondrial membranes;
Biological process	transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	11194
	74610
	ENSG00000197150
	ENSMUSG00000028973
	Q9NUT2
	Q9CXJ4
	NM_007188; NM_001282291; NM_001282292; NM_001282293
	NM_029020
	NP_001269220; NP_001269221; NP_001269222; NP_009119
	NP_083296
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.^[5]^[6]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028973 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
^ ^a ^b "Entrez Gene: ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8".

External links

ABCB8 human gene location in the UCSC Genome Browser.
ABCB8 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028973 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8894702-5] Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.

[entrez-6] "Entrez Gene: ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8".

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[4]

[5]

[6]

ABCB8

See also

References

Further reading

External links