|
|
| HLA-B (alpha)-β2MG with bound peptide
|
major histocompatibility complex (human), class I, B63
|
| Alleles
|
*1516, *1517
|
| Structure (See HLA-B)
|
| Shared data
|
| Locus
|
chr.6 6p21.31
|
HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]
B63 is one of many split antigens of the broad antigen, B15. B63 identifies the B*1516 and B*1517 allele products.
Serotype
Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products[2]
| B*15 |
B15
|
B62 |
B63
|
B70 |
B71 |
B72
|
B75 |
B76 |
B77 |
Sample
|
| allele |
% |
% |
% |
% |
% |
% |
% |
% |
% |
size (N)
|
| *1516 |
3 |
|
80 |
|
|
|
|
|
|
816
|
| *1517 |
2 |
|
88 |
|
|
|
|
|
|
797
|
| Alleles link-out to IMGT/HLA Databease at EBI
|
Alleles
HLA B*1516 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
Ivory Coast Akan Adiopodoume |
4.6
|
|
Cameroon Bamileke |
3.2
|
|
USA African Americans (3) |
1.9
|
|
Italy South Campania |
1.6
|
|
United Arab Emerates |
1.5
|
|
Brazil |
1.4
|
|
Azores S. Maria and S. Miguel |
1.3
|
|
Zimbabwe Harare Shona |
1.3
|
|
Cameroon Beti |
1.1
|
|
Cameroon Yaounde |
1.1
|
|
Mali Bandiagara |
1.1
|
|
Tunisia Tunis |
1.1
|
|
Kenya Nandi |
1.0
|
|
Cape Verde SE Islands |
0.8
|
|
Kenya |
0.7
|
|
Uganda Kampala |
0.6
|
|
Brazil Belo Horizonte |
0.5
|
|
South African Natal Zulu |
0.5
|
|
Sudanese |
0.5
|
|
Tunisia |
0.5
|
|
Kenya Luo |
0.4
|
|
Oman |
0.4
|
HLA B*1517 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
India Khandesh Pawra |
9.0
|
|
South Africa Natal Tamil |
3.1
|
|
Saudi Arabia Guraiat and Hail |
2.7
|
|
Mexico Zaptotec Oaxaca |
2.2
|
|
India North Hindus |
1.9
|
|
Bulgaria |
1.8
|
|
India North Delhi |
1.6
|
|
China Inner Mongolia |
1.5
|
|
Georgia Tbilisi Georgians |
1.4
|
|
Kenya Luo |
1.3
|
|
Cuban Mulatto |
1.2
|
|
Brazil Belo Horizonte |
1.1
|
|
Cameroon Yaounde |
1.1
|
|
Portugal North |
1.1
|
|
Tunisia Tunis |
1.1
|
|
Kenya Nandi |
1.0
|
|
Portugal Centre |
1.0
|
|
China Qinghai Hui |
0.9
|
|
Israel Ashk. and Non Ashk.i Jews |
0.9
|
|
Azores Terceira Island |
0.8
|
|
Cape Verde Southeastern Islands |
0.8
|
|
France South East |
0.8
|
|
India New Delhi |
0.8
|
|
Russia Tuva pop 2 |
0.8
|
|
Sudanese |
0.8
|
|
USA African Americans pop3 |
0.8
|
|
USA Caucasian pop2 |
0.8
|
|
Brazil |
0.7
|
|
Cuban White |
0.7
|
|
Thailand |
0.7
|
|
USA Philadelphia Caucasians |
0.7
|
|
Cameroon Beti |
0.6
|
|
Romanian |
0.6
|
|
Czech Republic |
0.5
|
|
Singapore Thai |
0.5
|
|
Spain Eastern Andalusia Gipsy |
0.5
|
References
- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ derived from IMGT/HLA
- ^ a b Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.