|
|
| HLA-B62 with bound peptide
|
major histocompatibility complex (human), class I, B62
|
| Alleles
|
*1501, *1504, *1507, *1525
|
| Structure (See HLA-B)
|
| Shared data
|
| Locus
|
chr.6 6p21.31
|
HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]
B62 is the largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507 B*1525 and B*1533 allele products.
Serotype
Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77
recognition of the HLA B*15 gene products[2]
| B*15 |
B15
|
B62 |
B63
|
B70 |
B71 |
B72
|
B75 |
B76 |
B77 |
Sample
|
| allele |
% |
% |
% |
% |
% |
% |
% |
% |
% |
size (N)
|
| *1501 |
2 |
96 |
|
|
|
|
|
|
|
1906
|
| *1504 |
10 |
69 |
|
|
|
|
|
|
|
29
|
| *1505 |
18 |
64 |
|
|
|
|
|
|
|
22
|
| *1506 |
|
40 |
|
20 |
|
|
11 |
|
|
10
|
| *1507 |
|
79 |
|
|
|
|
|
|
|
101
|
| *1508 |
|
20 |
|
|
|
|
18 |
|
|
45
|
| *1511 |
15 |
27 |
|
|
|
|
21 |
|
|
68
|
| *1512 |
17 |
18 |
|
|
|
|
|
8 |
|
12
|
| *1515 |
13 |
49 |
|
|
|
|
28 |
|
|
138
|
| *1520 |
|
100 |
|
|
|
|
|
|
|
5
|
| *1524 |
|
44 |
|
|
|
|
|
|
|
54
|
| *1525 |
7 |
74 |
|
|
|
|
8 |
|
|
116
|
| *1527 |
7 |
76 |
|
|
|
|
|
|
|
76
|
| *1528 |
14 |
57 |
|
|
|
|
14 |
|
|
7
|
| *1530 |
17 |
64 |
|
|
|
|
|
|
|
98
|
| *1531 |
|
50 |
|
|
|
|
|
|
|
12
|
| *1535 |
|
79 |
|
|
|
|
|
|
|
34
|
| Allele |
B15 |
B62 |
B63 |
B70 |
B71 |
B72 |
B75 |
B76 |
B77 |
N
|
| Alleles link-out to IMGT/HLA Databease at EBI
|
Alleles
HLA B*1501 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
Japan Ainu Hokkaido |
29.0
|
|
Chihuahuan Tarahumara |
14.8
|
|
Autonomous Tibetans |
12.3
|
|
South Korea ( 3) |
10.5
|
|
Japan Central |
8.7
|
|
Japan pop3 |
7.5
|
|
USA North American Natives |
7.2
|
|
South Dakota Lakota Sioux |
7.1
|
|
Shijiazhuang Tianjian Han |
7.0
|
|
China Qinghai Hui |
6.8
|
|
Croatia |
6.7
|
|
Japan pop5 |
6.5
|
|
Portugal Centre |
6.0
|
|
Taiwan Rukai |
6.0
|
|
USA Alaska Yupik Natives |
5.8
|
|
Australia New South Wales |
5.6
|
|
USA European Americans (2) |
5.6
|
|
France South East |
5.5
|
|
China Beijing |
5.3
|
|
Czech Republic |
4.7
|
|
Ireland South |
4.6
|
|
Mexico Sonora Seri |
4.5
|
|
China Inner Mongolia |
4.4
|
|
Russia Tuva (2) |
4.2
|
|
Singapore Chinese |
4.0
|
|
Taiwan Paiwan |
3.9
|
|
China North Han |
3.8
|
|
Georgia Svaneti Svans |
3.8
|
|
Ireland Northern |
3.8
|
|
Italy North Pavia |
3.7
|
|
Mexico Mestizos |
3.7
|
|
Azores Central Islands |
3.6
|
|
Madeira |
3.5
|
|
Taiwan Minnan pop 1 |
3.4
|
|
Azores Terceira Island |
3.1
|
|
Taiwan Siraya |
2.9
|
|
USA Hispanic |
2.8
|
|
Taiwan Hakka |
2.7
|
|
Taiwan Pazeh |
2.7
|
|
China Yunnan Nu |
2.6
|
|
Uganda Kampala |
2.5
|
|
Argentina Toba Rosario |
2.3
|
|
Romanian |
2.3
|
|
Hong Kong Chinese |
2.2
|
|
India North Hindus |
1.9
|
|
New Caledonia |
1.9
|
|
Italy South Campania |
1.8
|
|
Taiwan Thao |
1.7
|
|
India North Delhi |
1.6
|
|
China Guangzhou |
1.5
|
|
China Guangxi Maonan |
1.4
|
|
China Yunnan Lisu |
1.4
|
|
Thailand |
1.4
|
|
PNG New Britain Rabaul |
1.3
|
|
Brazil Belo Horizonte |
1.1
|
|
Cameroon Yaounde |
1.1
|
|
Portugal North |
1.1
|
|
United Arab Emerates |
1.1
|
|
Thailand pop3 |
1.0
|
|
USA African America |
1.0
|
|
USA African Americans |
1.0
|
|
Indig. Australian Yuendumu |
0.8
|
|
PNG Wanigela |
0.8
|
|
Mexico Zaptotec Oaxaca |
0.7
|
|
Spain Eastern Andalusia |
0.6
|
|
South African Natal Zulu |
0.5
|
|
Spain E. Andalusia Gipsy |
0.5
|
|
Sudanese |
0.5
|
|
Taiwan Bunun |
0.5
|
HLA B*1515 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
Mexico Mestizos |
2.4
|
|
Mex. Guadalajara Mestizos (2) |
1.9
|
|
Argentina Toba Rosario |
1.2
|
|
China Guangdong Meizhou Han |
1.0
|
|
China North Han |
1.0
|
|
Cape Verde NW Islands |
0.8
|
|
USA South Texas Hispanics |
0.8
|
|
USA San Antonio Caucasians |
0.6
|
|
USA Hispanic |
0.4
|
|
USA Asian |
0.3
|
|
USA North American Natives |
0.3
|
|
USA African America |
0.2
|
|
Hong Kong Chinese |
0.1
|
HLA B*1525 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
Taiwan Tao |
40.0
|
|
Taiwan Thao |
11.7
|
|
Taiwan Pazeh |
10.9
|
|
China Yunnan Lisu |
8.7
|
|
China Yunnan Nu |
8.3
|
|
PNG West Schrader Ranges |
8.2
|
|
Indig. Australian Groote Eylandt |
8.0
|
|
Taiwan Puyuma |
7.0
|
|
Taiwan Rukai |
7.0
|
|
Taiwan Bunun |
6.4
|
|
Indig. Australian Yuendumu |
5.7
|
|
Taiwan Siraya |
4.9
|
|
Taiwan Tsou |
4.9
|
|
Philippines Ivatan |
3.0
|
|
Taiwan Atayal |
2.8
|
|
Taiwan Ami |
2.6
|
|
Thailand |
2.5
|
|
China Guangzhou |
2.0
|
|
Thailand pop3 |
2.0
|
|
Hong Kong Chinese |
1.9
|
|
PNG Wanigela |
1.5
|
|
PNG Wosera |
1.5
|
|
Singapore Thai |
1.5
|
|
India Andhra Pradesh Golla |
1.4
|
|
PNG Eastern Highlands Goroka |
1.4
|
|
China South Han |
1.1
|
|
China Inner Mongolia |
1.0
|
|
India North Hindus |
1.0
|
HLA B*1507 frequencies
|
|
freq
|
| ref. |
Population |
(%)
|
| [3] |
Argentina Toba Rosario |
8.1
|
|
New Mexico Canoncito Navajo |
3.7
|
|
Brazil Terena |
2.6
|
|
USA North American Natives |
0.8
|
|
Japan Central |
0.7
|
|
South Korea pop 3 |
0.6
|
|
Japan pop3 |
0.4
|
|
USA Asian |
0.4
|
|
Shijiazhuang Tianjian Han |
0.3
|
|
USA Caucasian pop2 |
0.2
|
|
Hong Kong Chinese |
0.1
|
|
Ireland Northern |
0.1
|
References
- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ derived from IMGT/HLA
- ^ a b c d Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.