HLA-B49




major histocompatibility complex (human), class I, B49
Alleles	B4901, B4902, B*4903
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*4901
	B*4902
	B*4903
Locus	chr.6 6p21.31

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.^[1] The serotype identifies the more common HLA-B*50 gene products.^[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B49 and B21 serotype recognition of some more common HLA B*49 alleles^[3]
B*49	B49	B21	Sample
allele	%	%	size (N)
4901	94	1	3002

Allele distribution

**HLA B*4901 frequencies**
		freq
ref.	Population	(%)
^[4]	Portugal North	8.7
^[4]	Spain Basque Gipuzkoa Province	6.1
^[4]	Madeira	5.9
^[4]	Cameroon Yaounde	5.4
^[4]	Morocco Nador Metalsa (Berber)	5.1
^[4]	Kenya Nandi	4.6
^[4]	Sudanese	4.3
^[4]	Portugal South	4.1
^[4]	Tunisia Tunis	4.0
^[4]	India Jalpaiguri Toto	3.8
^[4]	Senegal Niokholo Mandenka	3.7
^[4]	Uganda Kampala	3.7
^[4]	Spain Eastern Andalusia	3.5
^[4]	Tunisia	3.5
^[4]	Georgia Tbilisi Kurds	3.4
^[4]	Spain Catalonia Girona	3.4
^[4]	Italy North (1)	3.3
^[4]	Cameroon Beti	3.2
^[4]	Israel Ashkenazi and Non Ashkenazi Jews	3.2
^[4]	Guinea Bissau	3.1
^[4]	France South East	2.7
^[4]	Israel Arab Druse	2.5
^[4]	Mali Bandiagara	2.5
^[4]	Jordan Amman	2.4
^[4]	Tunisia Ghannouch	2.4
^[4]	Georgia Tbilisi Georgians	2.3
^[4]	Saudi Arabia Guraiat and Hail	2.2
^[4]	Cameroon Bamileke	1.9
^[4]	Czech Republic	1.9
^[4]	Georgia Svaneti Svans	1.9
^[4]	Macedonia (4)	1.9
^[4]	Bulgaria	1.8
^[4]	Romanian	1.6
^[4]	Italy Bergamo	1.1
^[4]	Zambia Lusaka	1.1
^[4]	Belgium	1.0
^[4]	China North Han	1.0
^[4]	India Andhra Pradesh Golla	1.0
^[4]	Ireland Northern	1.0
^[4]	South African Natal Zulu	1.0

References

^ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

[pmid1385528-1] Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.

[pmid15787720-2] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[3] rived from IMGT/HLA

[pmid12753660-4] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

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