THC methylcarbonate

THC methylcarbonate
Identifiers
  • (6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-yl methylcarbonate
Chemical and physical data
FormulaC23H32O4
Molar mass372.505 g·mol−1
3D model (JSmol)
  • COC(=O)Oc1cc(CCCCC)cc2OC(C)(C)[C@@H]3CCC(C)=C[C@H]3c21
  • InChI=1S/C23H32O4/c1-6-7-8-9-16-13-19(26-22(24)25-5)21-17-12-15(2)10-11-18(17)23(3,4)27-20(21)14-16/h12-14,17-18H,6-11H2,1-5H3/t17-,18-/m1/s1
  • Key:OCIMDWOTFKKSJV-QZTJIDSGSA-N

THC methylcarbonate (Δ9-THC-methylcarbonate) is a semi-synthetic derivative of tetrahydrocannabinol, first reported as a designer drug in August 2024 when it was identified in a seized shipment by customs in Sweden.[1][2] Coincidentally, it was the 1000th new psychoactive substance identified by the EU Early Warning System on New Psychoactive Substances, first established in 1997.[3]

Related THC carbonates and carbamates have been described as THC prodrugs in the patent literature.[4]

See also

References

  1. ^ "EU‑EWS‑RCS‑FN‑2024‑0047: Formal Notification of delta‑9‑THC‑methylcarbonate" (PDF). EUDA Action on New Drugs Sector. 2024-12-18. Retrieved 2025-06-12.
  2. ^ "EDR 2025: Full Book (6 June 2025 – English version)" (PDF). European Union Drug Report (EUDA). 2025-06-06. Retrieved 2025-06-12.
  3. ^ "The EU Early Warning System monitors 1000 NPS". European Union Drugs Agency (EUDA). 2024-12-19. Retrieved 2025-06-12.
  4. ^ US 8,227,627 B2, Stinchcomb AL, Golinski MJ, Hammell DC, Howard JL, published 2007‑11‑30, issued 2012‑07‑24, assigned to Alltranz Inc. (original); Zynerba Pharmaceuticals Inc. (current) 
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