Phosphomevalonate kinase

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Phosphomevalonate kinase
Phosphomevalonate kinase
Identifiers
EC no.	2.7.4.2
CAS no.	9026-46-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

PMVK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CH4
Identifiers
Aliases	PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDs	OMIM: 607622; MGI: 1915853; HomoloGene: 4779; GeneCards: PMVK; OMA:PMVK - orthologs
EC number	2.7.4.2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,936,719 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,376,320 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lobe of liver; ; anterior pituitary; ; nucleus accumbens; ; C1 segment; ; skin of abdomen; ; anterior cingulate cortex; ; skin of leg; ; right adrenal cortex; ; right auricle of heart;
	Top expressed in
	fossa; ; lip; ; condyle; ; motor neuron; ; facial motor nucleus; ; trigeminal ganglion; ; ectoderm; ; otic placode; ; supraoptic nucleus; ; otic vesicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; kinase activity; phosphomevalonate kinase activity;
Cellular component	cytoplasm; cytosol; peroxisome; extracellular exosome; membrane;
Biological process	cholesterol biosynthetic process; steroid metabolic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; response to cholesterol; cholesterol metabolic process; sterol biosynthetic process; isoprenoid biosynthetic process; phosphorylation; lipid metabolism; steroid biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10654
	68603
	ENSG00000163344
	ENSMUSG00000027952
	Q15126
	Q9D1G2
	NM_006556; NM_001323011; NM_001323012; NM_001348696
	NM_026784; NM_027348; NM_001310640
	NP_001309940; NP_001309941; NP_006547; NP_001335625
	NP_001297569; NP_081060; NP_081624
	Wikidata
View/Edit Human	View/Edit Mouse

Identifiers

Symbol

PMVK

Other data

Chr. 1 p13-q23

Search for
Structures	Swiss-model
Domains	InterPro

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway^[5]^[6]^[7] that in humans is encoded by the PMVK gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.
^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

External links

Phosphomevalonate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.

[6] Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.

[7] Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

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Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)