Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[5][6][7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[8] and has been proposed as a potential therapeutic target in gliomas.[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[8]
Cancer biomarker
In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–40554. doi:10.1074/jbc.M107338200. PMID 11504738.
- ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–5121. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
- ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
- ^ a b c d Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, et al. (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
- ^ a b Ren J, Huang P, Wang F (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118.
- ^ Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, et al. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1): 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells". Biochem. J. 373 (Pt 2): 409–421. doi:10.1042/BJ20030343. PMC 1223506. PMID 12708969.
- Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res. 63 (10): 2665–2674. PMID 12750295.
- Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–664. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
- Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. Cell Biol. 163 (5): 1167–1177. doi:10.1083/jcb.200309113. PMC 2173626. PMID 14662754.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013–3019. doi:10.1182/blood-2003-07-2201. PMID 15070678.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–12985. doi:10.1074/jbc.M510617200. PMID 16537545.
- Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–19675. doi:10.1074/jbc.M602116200. PMID 16690612.
- Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells". Mol. Cell. Biol. 27 (21): 7718–7726. doi:10.1128/MCB.00180-07. PMC 2169036. PMID 17785435.
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