Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[5][6]
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.[7][8][9][10] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms.[6] CD37 controls both humoral[11][12] and cellular immune responses.[13][14][15] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma,[16] and patients with CD37-negative lymphomas have a worse clinical outcome.[17]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000104894 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030798 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–5. doi:10.1007/BF00222471. hdl:10138/157839. PMID 8436422. S2CID 8899453.
- ^ a b "Entrez Gene: CD37 CD37 molecule".
- ^ Levy S, Shoham T (February 2005). "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2): 136–48. doi:10.1038/nri1548. PMID 15688041. S2CID 1756810.
- ^ Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2): 133–54. doi:10.1042/BJ20082422. PMID 19426143.
- ^ Hemler ME (October 2005). "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10): 801–11. doi:10.1038/nrm1736. PMID 16314869. S2CID 5906694.
- ^ van Deventer SJ, Dunlock VE, van Spriel AB (2017-06-15). "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3): 741–750. doi:10.1042/BST20160284. PMID 28620035.
- ^ van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, et al. (March 2009). "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens. 5 (3): e1000338. doi:10.1371/journal.ppat.1000338. PMC 2650281. PMID 19282981.
- ^ van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, et al. (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250): ra82. doi:10.1126/scisignal.2003113. PMID 23150881. S2CID 21237789.
- ^ Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, et al. (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15): 5363–9. doi:10.1128/MCB.20.15.5363-5369.2000. PMC 85988. PMID 10891477.
- ^ van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, et al. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID 14978098. S2CID 5620186.
- ^ Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, et al. (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1): 50–5. doi:10.1002/eji.200838798. PMID 19089816. S2CID 46297687.
- ^ de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, et al. (February 2016). "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2): 653–66. doi:10.1172/JCI81041. PMC 4731177. PMID 26784544.
- ^ Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, et al. (December 2016). "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26): 3083–3100. doi:10.1182/blood-2016-05-715094. PMC 5201094. PMID 27760757.
Further reading
- Horejsí V, Vlcek C (August 1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Letters. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540. S2CID 26316623.
- Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (September 1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 172 (3): 1007. doi:10.1084/jem.172.3.1007. PMC 2188538. PMID 2388030.
- Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I (April 1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine. 169 (4): 1497–502. doi:10.1084/jem.169.4.1497. PMC 2189247. PMID 2466944.
- Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (February 1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". Journal of Immunology. 140 (3): 905–14. doi:10.4049/jimmunol.140.3.905. PMID 3257508. S2CID 23948434.
- Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics. 39 (4): 249–56. doi:10.1007/BF00188787. PMID 8119731. S2CID 20252327.
- Wright MD, Rochelle JM, Tomlinson MG, Seldin MF, Williams AF (February 1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". International Immunology. 5 (2): 209–16. doi:10.1093/intimm/5.2.209. PMID 8452817.
- Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, et al. (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
- Okochi H, Mine T, Nashiro K, Suzuki J, Fujita T, Furue M (July 1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". Journal of Clinical Gastroenterology. 29 (1): 63–7. doi:10.1097/00004836-199907000-00016. PMID 10405235.
- Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". International Archives of Allergy and Immunology. 120 (Suppl 1): 38–44. doi:10.1159/000053592. PMID 10529602. S2CID 39289159.
- van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, et al. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID 14978098. S2CID 5620186.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Meyer-Wentrup F, Figdor CG, Ansems M, Brossart P, Wright MD, Adema GJ, et al. (January 2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". Journal of Immunology. 178 (1): 154–62. doi:10.4049/jimmunol.178.1.154. PMID 17182550.
- Zhao X, Lapalombella R, Joshi T, Cheney C, Gowda A, Hayden-Ledbetter MS, et al. (October 2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood. 110 (7): 2569–77. doi:10.1182/blood-2006-12-062927. PMC 1988922. PMID 17440052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
|---|
| 1–50 | |
|---|
| 51–100 | |
|---|
| 101–150 | |
|---|
| 151–200 | |
|---|
| 201–250 | |
|---|
| 251–300 | |
|---|
| 301–350 | |
|---|