VU6036864

VU6036864
Identifiers
	IUPAC name 5-[4-(7-chloro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,2,6,6-tetradeuteriopiperidin-1-yl]sulfonyl-2-methyl-1,3-oxazole;
CAS Number	2746406-36-8;
PubChem CID	162361022;
Chemical and physical data
Formula	C15H12ClD4N5O3S
Molar mass	385.86 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [2H]C1(CC(CC(N1S(=O)(=O)C2=CN=C(O2)C)([2H])[2H])C3=CN4C(=NC=N4)C=C3Cl)[2H];
	InChI InChI=1S/C15H16ClN5O3S/c1-10-17-7-15(24-10)25(22,23)20-4-2-11(3-5-20)12-8-21-14(6-13(12)16)18-9-19-21/h6-9,11H,2-5H2,1H3/i4D2,5D2; Key:URAUBDCJGRESTK-CQOLUAMGSA-N;

VU6028418 is an experimental drug that acts as a potent and selective antagonist of the Muscarinic acetylcholine receptor M5. It has superior potency and selectivity compared to older ligands for this receptor and will be useful to characterise its effects, which have previously been difficult to separate from other muscarinic acetylcholine receptors.^[1]

References

^ Li J, Orsi DL, Engers JL, Long MF, Capstick RA, Maurer MA, et al. (August 2024). "Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M₅ Muscarinic Acetylcholine Receptor". Journal of Medicinal Chemistry. 67 (16): 14394–14413. doi:10.1021/acs.jmedchem.4c01193. PMC 11345818. PMID 39105778.

[1] Li J, Orsi DL, Engers JL, Long MF, Capstick RA, Maurer MA, et al. (August 2024). "Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M₅ Muscarinic Acetylcholine Receptor". Journal of Medicinal Chemistry. 67 (16): 14394–14413. doi:10.1021/acs.jmedchem.4c01193. PMC 11345818. PMID 39105778.

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