UQCRH

UQCRH
Identifiers
Aliases	UQCRH, QCR6, UQCR8, ubiquinol-cytochrome c reductase hinge protein
External IDs	OMIM: 613844; MGI: 3641869; HomoloGene: 103848; GeneCards: UQCRH; OMA:UQCRH - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,316,776 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; left ventricle; ; apex of heart; ; right auricle of heart; ; primary visual cortex; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; cerebellar hemisphere; ; Brodmann area 9;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquinol-cytochrome-c reductase activity;
Cellular component	mitochondrial inner membrane; respirasome; membrane; mitochondrion; mitochondrial respirasome; mitochondrial respiratory chain complex III;
Biological process	aerobic respiration; oxidative phosphorylation; proton transmembrane transport; mitochondrial electron transport, ubiquinol to cytochrome c;
	Sources:Amigo / QuickGO
Orthologs
	7388
	100042918
	ENSG00000173660
	ENSMUSG00000037438
	P07919
	n/a
	NM_006004; NM_001297565; NM_001297566
	n/a
	NP_001284494; NP_001284495; NP_005995
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^[4]^[5]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173660 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett. 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.
^ "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein". Archived from the original on 2024-04-28. Retrieved 2017-09-17.

Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer". Cancer Res. 53 (11): 2460–5. PMID 7684318.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene. 22 (29): 4586–93. doi:10.1038/sj.onc.1206472. hdl:11380/740804. PMID 12881716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173660 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2826252-4] Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett. 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.

[entrez-5] "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein". Archived from the original on 2024-04-28. Retrieved 2017-09-17.

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References

Further reading