Tubular carcinoma

Tubular carcinoma is a subtype of invasive ductal carcinoma of the breast.[2][3] More rarely, tubular carcinomas may arise in the pancreas[4] or kidney.[5] Most tubular carcinomas begin in the milk duct of the breast and spread to healthy tissue around it.[6][7]

Pathology

Although tubular carcinoma has been considered a special-type tumor,[a] recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS[b] carcinomas with tubular features, depending on the percentage of the lesion that displays tubular features.[10]: 647 

Histology

Tubular carcinomas are generally around 1 cm. or smaller, and are made up of tubules. They are usually low-grade.[2] Elastosis has been noted as common but is not present in all cases.[11]

Prevalence

Prevalence has previously been controversial, with contradictory reports from studies reporting either very low prevalence, or a high prevalence.[10] With the increasing availability of screening mammography, however, tubular carcinomas are being diagnosed earlier, and more recent studies suggest tubular carcinomas represent between 8% and 27% of all breast cancers.[2]

Prognosis

Tubular carcinoma is one of the histologic types of breast cancer with a more favorable outcome.[12]

See also

Notes and references

Notes
  1. ^ Special-type tumor: such as mucinous and cribriform carcinomas.[8]
  2. ^ NOS: of type "Not Otherwise Specified".[9]
References
  1. ^ a b Image by Mikael Häggström, MD. Reference for typical features: Pragya Virendrakumar Jain, M.D., Julie M. Jorns, M.D. "Breast - Other invasive carcinoma subtypes, WHO classified - Tubular". Pathology Outlines.{{cite web}}: CS1 maint: multiple names: authors list (link) Last author update: 23 March 2023
  2. ^ a b c Hudis, Kenneth (22 June 2019). "IDC Type: Tubular Carcinoma of the Breast". Breastcancer.org. Retrieved 26 February 2022.
  3. ^ Limaiem, Faten; Mlika, Mouna (2022). "Tubular Breast Carcinoma". StatPearls. StatPearls Publishing. PMID 31194380. Retrieved 3 March 2022.
  4. ^ Chelliah, Adeline; Kalimuthu, Sangeetha; Chetty, Runjan (October 2016). "Intraductal tubular neoplasms of the pancreas: an overview". Ann Diagn Pathol. 24 (24:68–72): 68–72. doi:10.1016/j.anndiagpath.2016.04.009. PMID 27185640.
  5. ^ Zhao, Ming; He, Xiang-lei; Teng, Xiao-dong (December 2015). "Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects". Diagnostic Pathology. 10 (1): 168. doi:10.1186/s13000-015-0402-1. PMC 4573286. PMID 26377921.
  6. ^ Musser, Robert (2009). The P.I.N.K. Primer. Dog Ear Publishing. pp. 20–. ISBN 978-1-60844-176-1.
  7. ^ Feng, Yixiao; Spezia, Mia; Huang, Shifeng; Yuan, Chengfu; Zeng, Zongyue; Zhang, Linghuan; Ji, Xiaojuan; Liu, Wei; Huang, Bo; Luo, Wenping; Liu, Bo; Lei, Yan; Du, Scott; Vuppalapati, Akhila; Luu, Hue H.; Haydon, Rex C.; He, Tong-Chuan; Ren, Guosheng (June 2018). "Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis". Genes & Diseases. 5 (2): 77–106. doi:10.1016/j.gendis.2018.05.001. PMC 6147049. PMID 30258937.
  8. ^ "Understanding Your Pathology Report: Breast Cancer", Cancer.org, American Cancer Society, 2022, retrieved 26 February 2022
  9. ^ "Farlex Partner Medical Dictionary". 2009. not otherwise specified. Retrieved 26 February 2022.
  10. ^ a b Stavros, A. Thomas (2004). Rapp, Cynthia L.; Parker, Steve H. (eds.). Breast Ultrasound. Lippincott Williams & Wilkins. pp. 647–649. ISBN 978-0-397-51624-7. OCLC 1065689596. p. 649: A highly differentiated invasive carcinoma that forms well-defined tubules (containing epithelium, but no myoepithelium) and that have abundant desmoplastic fibrous stromal reaction between the tubules.
  11. ^ Rosen, Paul Peter, ed. (2001). Rosen's Breast Pathology. Lippincott Williams & Wilkins. pp. 373–. ISBN 978-0-7817-2379-4. OCLC 1117861419.
  12. ^ "Breast Cancer Treatment (Adult) (PDQ®)–Health Professional Version". National Cancer Institute. 20 January 2022. Retrieved 26 February 2022.
  13. ^ Demir S, Sezgin G, Sari AA, Kucukzeybek BB, Yigit S, Etit D, Yazici A, Kucukzeybek Y (October 2021). "Clinicopathological analysis of invasive cribriform carcinoma of the breast, with review of the literature". Annals of Diagnostic Pathology. 54: 151794. doi:10.1016/j.anndiagpath.2021.151794. PMID 34325338.

Further reading


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