TVP23B

TVP23B
Identifiers
Aliases	TVP23B, FAM18B, FAM18B1, NPD008, YDR084C, CGI-148, trans-golgi network vesicle protein 23 homolog B (S. cerevisiae), trans-golgi network vesicle protein 23 homolog B
External IDs	MGI: 1914760; HomoloGene: 128511; GeneCards: TVP23B; OMA:TVP23B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,806,714 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,807,606 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Achilles tendon; ; stromal cell of endometrium; ; mucosa of esophagus; ; gonad; ; olfactory zone of nasal mucosa; ; body of pancreas; ; rectum; ; anterior pituitary; ; gallbladder;
	Top expressed in
	otolith organ; ; utricle; ; vestibular sensory epithelium; ; superior cervical ganglion; ; lobe of prostate; ; olfactory epithelium; ; parotid gland; ; seminal vesicula; ; ciliary body; ; submandibular gland;
	More reference expression data
	n/a
Orthologs
	51030
	67510
	ENSG00000171928
	ENSMUSG00000014177
	Q9NYZ1
	Q9D8T4
NM_016078; NM_001316919; NM_001316920; NM_001316921; NM_001316922;
	NM_001316923; NM_001316924
	NM_026210; NM_001356520; NM_001356521
NP_001303848; NP_001303849; NP_001303850; NP_001303851; NP_001303852;
	NP_001303853; NP_057162
	NP_080486; NP_001343449; NP_001343450
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi apparatus membrane protein TVP23 homolog B is a protein encoded by the gene TVP23B.

This gene has two paralog in the human genome, TVP23C, which is located on chromosome 17 at 17p12, and TVP23A, which is located on chromosome 16. The duplication appears to have appeared after the MRCA of humans and apes. This gene has homologs in eukaryotes as far back as Trichoplax.

Gene

TVP23B is highly conserved in chordates and also shows conservation in eukaryotes, including fungi and plants.^[5] The most common mRNA has 7 exons.

Protein

This gene encode a protein of 205 amino acids in length and a predicted molecular weight of 23.57 kDa. This protein is predicted to have an isoelectric point of 8.62. It contains a domain of unknown function, DUF846, and a predicted phosphoserine site.^[6] It is a multipass transmembrane protein and a member of the FAM18/TVP23 superfamily.

TVP23B appears to be ubiquitously expressed in all tissues, health states, and developmental stages to some level. There is also notable expression in bladder tissue.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171928 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014177 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Pre-computed BLAST results for LOC51030 [Homo sapiens]". BLINK ("BLAST Link"). National Center for Biotechnology Information, United States National Institutes of Health.
^ "UniProt Database".
^ "EST Profile Database".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171928 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014177 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[urlBLINK-5] "Pre-computed BLAST results for LOC51030 [Homo sapiens]". BLINK ("BLAST Link"). National Center for Biotechnology Information, United States National Institutes of Health.

[Uniprot-6] "UniProt Database".

[EST_Profile-7] "EST Profile Database".

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