TRA2A

TRA2A
Identifiers
Aliases	TRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718; MGI: 1933972; HomoloGene: 40866; GeneCards: TRA2A; OMA:TRA2A - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	23,532,041 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	49,240,967 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; buccal mucosa cell; ; right ovary; ; ganglionic eminence; ; left ovary; ; ventricular zone; ; canal of the cervix; ; sural nerve; ; body of uterus; ; right lobe of thyroid gland;
	Top expressed in
	pineal gland; ; Gonadal ridge; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; tail of embryo; ; dermis; ; superior cervical ganglion; ; epiblast; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; RNA binding;
Cellular component	nucleolus; intracellular membrane-bounded organelle; nucleus; ribonucleoprotein complex;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	29896
	101214
	ENSG00000164548
	ENSMUSG00000029817
	Q13595
	Q6PFR5
NM_001282757; NM_001282758; NM_001282759; NM_013293; NM_001362759;
	NM_001362760; NM_001362761
	NM_198102; NM_001347209; NM_001362188
NP_001269686; NP_001269687; NP_001269688; NP_037425; NP_001349688;
	NP_001349689; NP_001349690
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.^[5]^[6]^[7]

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
^ Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
^ ^a ^b "Entrez Gene: TRA2A transformer-2 alpha".

Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–8. Bibcode:2004Natur.427..553S. doi:10.1038/nature02288. PMID 14765198. S2CID 4423246.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8799144-5] Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.

[pmid9546399-6] Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.

[entrez-7] "Entrez Gene: TRA2A transformer-2 alpha".

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References

Further reading