Stimulator of chondrogenesis 1

SCRG1
Identifiers
Aliases	SCRG1, SCRG-1, stimulator of chondrogenesis 1
External IDs	OMIM: 603163; MGI: 1328308; HomoloGene: 5269; GeneCards: SCRG1; OMA:SCRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	173,406,380 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	57,930,619 bp
RNA expression pattern
	Top expressed in
	tibia; ; external globus pallidus; ; subthalamic nucleus; ; saphenous vein; ; inferior ganglion of vagus nerve; ; pars reticulata; ; optic nerve; ; cartilage tissue; ; superior vestibular nucleus; ; pons;
	Top expressed in
	granulocyte; ; optic nerve; ; lumbar subsegment of spinal cord; ; globus pallidus; ; anterior amygdaloid area; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; entorhinal cortex; ; cerebellar vermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi apparatus; neuron projection terminus; extracellular region; cytoplasm; extracellular space;
Biological process	nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	11341
	20284
	ENSG00000164106
	ENSMUSG00000031610
	O75711
	O88745
	NM_007281; NM_001329597
	NM_009136
	NP_001316526; NP_009212
	NP_033162
	Wikidata
View/Edit Human	View/Edit Mouse

Stimulator of chondrogenesis 1 is a protein that in humans is encoded by the SCRG1 gene. ^[5]

Function

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164106 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031610 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Stimulator of chondrogenesis 1". Retrieved 2018-10-01.

Function

References

Further reading