SOX30

SOX30
Identifiers
Aliases	SOX30, SRY-box 30, SRY-box transcription factor 30
External IDs	OMIM: 606698; MGI: 1341157; HomoloGene: 34027; GeneCards: SOX30; OMA:SOX30 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,671,480 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	45,908,821 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; secondary oocyte; ; testicle; ; gonad; ; sperm; ; mucosa of transverse colon; ; stromal cell of endometrium; ; islet of Langerhans; ; right uterine tube;
	Top expressed in
	female urethra; ; spermatocyte; ; spermatid; ; seminiferous tubule; ; male urethra; ; embryo; ; retina; ; ovary; ; islet of Langerhans; ; urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	response to corticosteroid; regulation of transcription, DNA-templated; transcription, DNA-templated; spermatogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	11063
	214105
	ENSG00000039600
	ENSMUSG00000040489
	O94993
	Q8CGW4
	NM_001308165; NM_007017; NM_178424
	NM_173384
	NP_001295094; NP_008948; NP_848511
	NP_775560
	Wikidata
View/Edit Human	View/Edit Mouse

SRY (sex determining region Y)-box 30 is a protein that in humans is encoded by the SOX30 gene.^[5]

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000039600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040489 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SRY (sex determining region Y)-box 30". Retrieved 2014-05-29.

Koopman P, Schepers G, Brenner S, Venkatesh B (March 2004). "Origin and diversity of the SOX transcription factor gene family: genome-wide analysis in Fugu rubripes". Gene. 328: 177–186. doi:10.1016/j.gene.2003.12.008. PMID 15019997.
Osaki E, Nishina Y, Inazawa J, Copeland NG, Gilbert DJ, Jenkins NA, et al. (June 1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Research. 27 (12): 2503–2510. doi:10.1093/nar/27.12.2503. PMC 148454. PMID 10359848.
Fan BJ, Wang DY, Tham CC, Lam DS, Pang CP (May 2008). "Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone". Investigative Ophthalmology & Visual Science. 49 (5): 1886–1897. doi:10.1167/iovs.07-0414. PMID 18436822.
Bullejos M, Díaz de la Guardia R, Barragán MJ, Sánchez A (2000). "HMG-box sequences from microbats homologous to the human SOX30 HMG-box". Genetica. 110 (2): 157–162. doi:10.1023/A:1017914005677. PMID 11678506. S2CID 16100625.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000039600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040489 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SRY (sex determining region Y)-box 30". Retrieved 2014-05-29.

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Function

References

Further reading