Ras p21 protein activator 2

RASA2
Identifiers
Aliases	RASA2, GAP1M, RAS p21 protein activator 2
External IDs	OMIM: 601589; MGI: 2149960; HomoloGene: 4745; GeneCards: RASA2; OMA:RASA2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	141,615,344 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	96,631,617 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; superficial temporal artery; ; trabecular bone; ; nipple; ; tibia; ; skin of hip; ; visceral pleura; ; Brodmann area 23; ; parietal pleura; ; Achilles tendon;
	Top expressed in
	Rostral migratory stream; ; secondary oocyte; ; primary oocyte; ; zygote; ; median eminence; ; granulocyte; ; primary motor cortex; ; lymph node; ; mesenteric lymph nodes; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; GTPase activator activity; phospholipid binding;
Cellular component	cytoplasm; cytosol; intrinsic component of the cytoplasmic side of the plasma membrane; perinuclear region of cytoplasm;
Biological process	intracellular signal transduction; regulation of GTPase activity; MAPK cascade; positive regulation of GTPase activity; signal transduction; negative regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5922
	114713
	ENSG00000155903
	ENSMUSG00000032413
	Q15283
	P58069
	NM_001303245; NM_001303246; NM_006506
	NM_053268
	NP_001290174; NP_001290175; NP_006497
	NP_444498
	Wikidata
View/Edit Human	View/Edit Mouse

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene.^[5]

Function

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. It has been shown that RASA2 promotes a shift from noncanonical to canonical TGF-β signaling through SMAD3 in B cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032413 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.
^ Mamand, Sami (25 October 2024). "Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling". The Journal of Immunology. 213 (9). doi:10.4049/jimmunol.2400353. Retrieved 1 November 2024.

Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ (March 1999). "Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo". Curr. Biol. 9 (5): 265–8. doi:10.1016/s0960-9822(99)80116-x. PMID 10074452. S2CID 8695013.
Mamand, Sami; Liu, Heather; Kashem, Mohammad; Martin, Alberto (25 October 2024). "Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling". The Journal of Immunology. 213 (9). doi:10.4049/jimmunol.2400353. PMID 39451029.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032413 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.

[6] Mamand, Sami (25 October 2024). "Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling". The Journal of Immunology. 213 (9). doi:10.4049/jimmunol.2400353. Retrieved 1 November 2024.

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Function

References

Further reading