PREPL

PREPL
Identifiers
Aliases	PREPL, prolyl endopeptidase-like, CMS22, prolyl endopeptidase like
External IDs	OMIM: 609557; MGI: 2441932; HomoloGene: 15481; GeneCards: PREPL; OMA:PREPL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	44,361,862 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,397,669 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; postcentral gyrus; ; pars compacta; ; lateral nuclear group of thalamus; ; external globus pallidus; ; pons; ; pars reticulata; ; entorhinal cortex;
	Top expressed in
	ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; ventral tegmental area; ; pontine nuclei; ; medial geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; medial vestibular nucleus; ; inferior colliculi; ; central gray substance of midbrain;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	serine-type exopeptidase activity; peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cytoskeleton;
Biological process	proteolysis; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9581
	213760
	ENSG00000138078
	ENSMUSG00000024127
	Q4J6C6
	Q8C167
NM_001042385; NM_001042386; NM_001171603; NM_001171606; NM_001171613;
	NM_001171617; NM_006036; NM_001374275; NM_001374276; NM_001374277
	NM_001163622; NM_001163623; NM_001163624; NM_145984
NP_001035844; NP_001035845; NP_001165074; NP_001165077; NP_001165084;
	NP_001165088; NP_006027; NP_001361204; NP_001361205; NP_001361206
	NP_001157094; NP_001157095; NP_001157096; NP_666096
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene.^[5]^[6]

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138078 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024127 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC 1226072. PMID 11524703.
^ ^a ^b "Entrez Gene: PREPL prolyl endopeptidase-like".

Martens K, Derua R, Meulemans S, et al. (2006). "PREPL: a putative novel oligopeptidase propelled into the limelight". Biol. Chem. 387 (7): 879–883. doi:10.1515/BC.2006.111. PMID 16913837. S2CID 7983864.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl:10669/15162. PMID 7829101.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
Kim DK, Kanai Y, Choi HW, et al. (2002). "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells". Biochim. Biophys. Acta. 1565 (1): 112–122. doi:10.1016/S0005-2736(02)00516-3. PMID 12225859.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Parvari R, Gonen Y, Alshafee I, et al. (2005). "The 2p21 deletion syndrome: characterization of the transcription content". Genomics. 86 (2): 195–211. doi:10.1016/j.ygeno.2005.04.001. PMID 15913950.
Szeltner Z, Alshafee I, Juhász T, et al. (2005). "The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity". Cell. Mol. Life Sci. 62 (19–20): 2376–2381. doi:10.1007/s00018-005-5262-5. PMC 11139102. PMID 16143824. S2CID 11081394.
Jaeken J, Martens K, Francois I, et al. (2006). "Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome". Am. J. Hum. Genet. 78 (1): 38–51. doi:10.1086/498852. PMC 1380222. PMID 16385448.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138078 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024127 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11524703-5] Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC 1226072. PMID 11524703.

[entrez-6] "Entrez Gene: PREPL prolyl endopeptidase-like".

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References

Further reading