Oligoporin D

Oligoporin D
Identifiers
	IUPAC name (Z,6R)-6-[(3R,5R,10S,12R,13R,14R,17R)-3-oxo-4,4,10,13,14-pentamethyl-12-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,5,6,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid;
Chemical and physical data
Formula	C36H56O9
Molar mass	632.835 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@]12C[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C3=C(CC[C@@H]4[C@]3(C)CCC(=O)C4(C)C)[C@]2(C)CC[C@@H]1[C@H](C)CC\C=C(\C)C(=O)O;

Oligoporin D is a natural product isolated from the "bitter bracket" mushroom Amaropostia stiptica. It was found to be one of the most potent agonists yet discovered for the bitter taste receptor TAS2R46, and consequently one of the most bitter substances known.^[1]

References

^ Schmitz LM, Lang T, Steuer A, Koppelmann L, Di Pizio A, Arnold N, et al. (February 2025). "Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors". Journal of Agricultural and Food Chemistry. 73 (8): 4850–4858. Bibcode:2025JAFC...73.4850S. doi:10.1021/acs.jafc.4c12651. PMC 11869282. PMID 39945763.

[1] Schmitz LM, Lang T, Steuer A, Koppelmann L, Di Pizio A, Arnold N, et al. (February 2025). "Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors". Journal of Agricultural and Food Chemistry. 73 (8): 4850–4858. Bibcode:2025JAFC...73.4850S. doi:10.1021/acs.jafc.4c12651. PMC 11869282. PMID 39945763.

[1]