OR2T4

OR2T4
Identifiers
Aliases	OR2T4, OR1-60, OR2T4Q, olfactory receptor family 2 subfamily T member 4
External IDs	MGI: 3030058; HomoloGene: 133015; GeneCards: OR2T4; OMA:OR2T4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	248,362,627 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,461,379 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; Brodmann area 9; ; primary visual cortex; ; substantia nigra;
	Top expressed in
	esophagus; ; conceptus; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	127074
	258198
	ENSG00000196944; ENSG00000275617; ENSG00000274870
	ENSMUSG00000059279
	Q8NH00
	M9MMJ7
	NM_001004696
	NM_207695
	NP_001004696
	NP_997578
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:

References

^ ^a ^b ^c ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059279 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".
^ Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC 6482435. PMID 30977365.

External links

OR2T4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059279 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".

[6] Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC 6482435. PMID 30977365.

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OR2T4

Ligands

See also

References

Further reading

External links