NLRP8

NLRP8
Identifiers
Aliases	NLRP8, CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8
External IDs	OMIM: 609659; HomoloGene: 82360; GeneCards: NLRP8; OMA:NLRP8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,988,629 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATP binding; molecular function;
Cellular component	cytoplasm; cellular component;
Biological process	neuron death;
	Sources:Amigo / QuickGO
Orthologs
	126205
	n/a
	ENSG00000179709
	n/a
	Q86W28
	n/a
	NM_176811; NM_001317000
	n/a
	NP_001303929; NP_789781
	n/a
	Wikidata
View/Edit Human

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.^[3]^[4] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045. S2CID 2784688.
^ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9 (1): 202. Bibcode:2009BMCEE...9..202T. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.

Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia" (PDF). Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1