NEURL2

NEURL2
Identifiers
Aliases	NEURL2, C20orf163, OZZ, OZZ-E3, neuralized E3 ubiquitin protein ligase 2
External IDs	OMIM: 608597; MGI: 3043305; HomoloGene: 15435; GeneCards: NEURL2; OMA:NEURL2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,891,208 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,675,376 bp
RNA expression pattern
	Top expressed in
	testicle; ; apex of heart; ; gastric mucosa; ; gonad; ; muscle of thigh; ; tendon of biceps brachii; ; thymus; ; gastrocnemius muscle; ; right adrenal cortex; ; quadriceps femoris muscle;
	Top expressed in
	interventricular septum; ; vastus lateralis muscle; ; triceps brachii muscle; ; temporal muscle; ; myocardium of ventricle; ; ankle; ; muscle of thigh; ; sternocleidomastoid muscle; ; medial head of gastrocnemius muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity;
Cellular component	cytoplasm; cytosol;
Biological process	intracellular signal transduction; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	140825
	415115
	ENSG00000124257
	ENSMUSG00000039873
	Q9BR09
	Q9D0S4
	NM_080749; NM_001278535
	NM_001082974
	NP_001265464; NP_542787
	NP_001076443
	Wikidata
View/Edit Human	View/Edit Mouse

Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.^[5]^[6]

Function

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039873 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
^ ^a ^b "Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila)".

Song R, Koo BK, Yoon KJ, Yoon MJ, Yoo KW, Kim HT, et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1". J. Biol. Chem. 281 (47): 36391–400. doi:10.1074/jbc.M606601200. PMID 17003037.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy JN, Bostrom J, et al. (2004). "Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis". Dev. Cell. 6 (2): 269–82. doi:10.1016/S1534-5807(04)00020-6. PMID 14960280.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039873 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12076535-5] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-6] "Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila)".

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NEURL2

Function

See also

References

Further reading