Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene.[5]
The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA.[5] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103707 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059183 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Mitochondrial methionyl-tRNA formyltransferase". Retrieved 2011-09-20.
- ^ Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, et al. (September 2011). "Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation". Cell Metabolism. 14 (3): 428–434. doi:10.1016/j.cmet.2011.07.010. PMC 3486727. PMID 21907147.
Further reading