List of investigational sleep drugs
This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
This list was last comprehensively updated sometime between June 2017 and August 2021. It is likely to become outdated with time.
Insomnia
GABAA receptor potentiators
- Lorediplon (GF-015535-00) – GABAA receptor positive allosteric modulator [1]
- Zuranolone (SAGE-217) – GABAA receptor positive allosteric modulator [2]
Orexin receptor antagonists
- Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX2 receptor antagonist [3]
- Vornorexant (ORN-0829, TS-142) – dual OX1 and OX2 receptor antagonist [4]
Melatonin receptor agonists
- Piromelatine (Neu-P11) – melatonin receptor agonist and 5-HT1A and 5-HT1D receptor agonist [5]
Nociceptin receptor agonists
- Sunobinop (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist [6][7]
Narcolepsy
Orexin receptor agonists
- ALKS-2680 – selective OX2 receptor agonist[1]
- Danavorexton (TAK-925) – selective OX2 receptor agonist via IV infusion[2][8]
- E-2086 – selective OX2 receptor agonist[3]
- Firazorexton (TAK-994) – OX2 receptor agonist pill (orally available)[9][2]
- Oveporexton (TAK-861) – selective OX2 receptor agonist (orally available) [10][4]
- Suntinorexton – selective OX2 receptor agonist (orally available) [11][5]
Monoaminergics
- Flecainide/modafinil (THN-102) – modafinil (dopamine reuptake inhibitor) and flecainide (antiarrhythmic) combination [12]
- Mazindol controlled release (NLS-1001, NLS-1) – norepinephrine-predominant serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)[13]
- Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) [14]
GHB receptor agonists
H3 receptor inverse agonists
- Samelisant (SUVN-G3031) – H3 receptor antagonist [15]
GABAA receptor inhibitors
- Pentylenetetrazole (BTD-001) – GABAA receptor negative allosteric modulator [16]
See also
References
- ^ "ALKS 2680". AdisInsight. 7 June 2024. Retrieved 31 July 2024.
- ^ a b "Takeda". www.ox2rsparkleprogram.com. Retrieved 2019-11-15.
- ^ "E-2086". AdisInsight. 15 July 2024. Retrieved 31 July 2024.
- ^ "Oveporexton". AdisInsight. 16 December 2024. Retrieved 26 February 2025.
- ^ Konofal, Eric (2024). "From past to future: 50 years of pharmacological interventions to treat narcolepsy". Pharmacology Biochemistry and Behavior. 241: 173804. doi:10.1016/j.pbb.2024.173804.