List of highways numbered 221
The following highways are numbered 221:
Canada
- Manitoba Provincial Road 221
- Newfoundland and Labrador Route 221
- Nova Scotia Route 221
- Prince Edward Island Route 221
- Quebec Route 221
- Saskatchewan Highway 221
China
Cuba
- Santa Clara–Sagua Road (4–221)
Costa Rica
Japan
United Kingdom
- A221 road
- B221 road
United States
- U.S. Route 221
- Alabama State Route 221
- Arkansas Highway 221
- California State Route 221
- Florida State Road 221 (former)
- Georgia State Route 221 (former)
- Iowa Highway 221 (former)
- K-221 (Kansas highway) (former)
- Kentucky Route 221
- Maine State Route 221
- Minnesota State Highway 221 (former)
- Montana Secondary Highway 221
- Nevada State Route 221
- New Mexico State Road 221
- New York State Route 221
- Ohio State Route 221
- Oregon Route 221
- Pennsylvania Route 221
- Tennessee State Route 221
- Texas State Highway 221 (former)
- Texas State Highway Loop 221 (former)
- Utah State Route 221 (former)
- Washington State Route 221
- Wyoming Highway 221
| Preceded by 220 |
Lists of highways 221 |
Succeeded by 222 |