Katherine Henzler-Wildman

Katherine Henzler-Wildman
Alma materUniversity of Michigan
Scientific career
ThesisThe mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37 (2003)

Katherine Anne Henzler-Wildman is the Jean V. Thomas Professor in Biochemistry at the University of Wisconsin–Madison. She was elected a fellow of the American Association for the Advancement of Science in 2024. She is known for her work on how proteins control the movement of molecules across membranes.

Education and career

Henzler-Wildman received a B.A. from Cornell University in 1998.[1] She earned her Ph.D. from the University of Michigan in 2003.[2] She then moved to Brandeis University where she worked with Dorothee Kern as a postdoctoral researcher until 2008 when she joined the faculty at Washington University in St. Louis.[2] In 2015 moved to the University of Madison, and as of 2025 Henzler-Wildman is the Jean V. Thomas Professor in Biochemistry.[3]

Research

Henzler-Wildman's early research determined structural details of lipid membranes[4] and the dynamics of protein folding.[5] She has investigated the protein EmrE[6] and demonstrated how this protein pushes toxic molecules out of microbial cells.[7]

Selected publications

  • Henzler-Wildman, Katherine; Kern, Dorothee (2007-12-13). "Dynamic personalities of proteins". Nature. 450 (7172): 964–972. doi:10.1038/nature06522. ISSN 0028-0836.
  • Henzler-Wildman, Katherine A.; Lei, Ming; Thai, Vu; Kerns, S. Jordan; Karplus, Martin; Kern, Dorothee (2007). "A hierarchy of timescales in protein dynamics is linked to enzyme catalysis". Nature. 450 (7171): 913–916. doi:10.1038/nature06407. ISSN 0028-0836.
  • Henzler Wildman, Katherine A.; Lee, Dong-Kuk; Ramamoorthy, A. (2003-06-01). "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide, LL-37". Biochemistry. 42 (21): 6545–6558. doi:10.1021/bi0273563. ISSN 0006-2960.
  • Morrison, Emma A.; DeKoster, Gregory T.; Dutta, Supratik; Vafabakhsh, Reza; Clarkson, Michael W.; Bahl, Arjun; Kern, Dorothee; Ha, Taekjip; Henzler-Wildman, Katherine A. (2012). "Antiparallel EmrE exports drugs by exchanging between asymmetric structures". Nature. 481 (7379): 45–50. doi:10.1038/nature10703. ISSN 0028-0836. PMC 3253143. PMID 22178925.
  • Lewis, Adam; Kurauskas, Vilius; Tonelli, Marco; Henzler-Wildman, Katherine (2021-10-28). "Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel". Nature Communications. 12 (1). doi:10.1038/s41467-021-26538-8. ISSN 2041-1723. PMC 8553846. PMID 34711838.

Awards and honors

Henzler-Wildman was named a Searle Scholars Program in 2010,[8] and received the Margaret Oakley Dayhoff Award from the Biophysical Society in 2013.[9] She was elected a fellow of the American Association for the Advancement of Science in 2024.[10]

References

  1. ^ Gordon, Sharona E. (2015-01-26). "To better serve our community: Introducing new Associate Editors and an expanded Editorial Advisory Board for 2015". Journal of General Physiology. 145 (2): 83–90. doi:10.1085/jgp.201411352. ISSN 0022-1295. PMC 4306714. PMID 25624446.
  2. ^ a b "Katherine A. Henzler-Wildman, PhD". Washington University Medicine. Retrieved 2025-04-19.
  3. ^ "Henzler-Wildman, Katherine". Department of Biochemistry at the University of Wisconsin-Madison. 2019-09-19. Retrieved 2025-04-19.
  4. ^ Henzler Wildman, Katherine A.; Lee, Dong-Kuk; Ramamoorthy, A. (2003-06-01). "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide, LL-37". Biochemistry. 42 (21): 6545–6558. doi:10.1021/bi0273563. ISSN 0006-2960.
  5. ^ Henzler-Wildman, Katherine A.; Thai, Vu; Lei, Ming; Ott, Maria; Wolf-Watz, Magnus; Fenn, Tim; Pozharski, Ed; Wilson, Mark A.; Petsko, Gregory A.; Karplus, Martin; Hübner, Christian G.; Kern, Dorothee (2007). "Intrinsic motions along an enzymatic reaction trajectory". Nature. 450 (7171): 838–844. doi:10.1038/nature06410. ISSN 0028-0836.
  6. ^ Morrison, Emma A.; DeKoster, Gregory T.; Dutta, Supratik; Vafabakhsh, Reza; Clarkson, Michael W.; Bahl, Arjun; Kern, Dorothee; Ha, Taekjip; Henzler-Wildman, Katherine A. (2012). "Antiparallel EmrE exports drugs by exchanging between asymmetric structures". Nature. 481 (7379): 45–50. doi:10.1038/nature10703. ISSN 0028-0836. PMC 3253143. PMID 22178925.
  7. ^ Trafton, Anne (2022-02-25). "MIT Chemists Discover Structure of Protein That Pumps Toxic Molecules Out of Bacterial Cells". SciTechDaily. Retrieved 2025-04-19.
  8. ^ Ericson, Gwen (2010-05-06). "Washington University biochemist named 2010 Searle Scholar". The Source. Retrieved 2025-04-19.
  9. ^ "Biophysical Society Names Six 2013 Award Recipients" (PDF). Archived from the original (PDF) on 2018-03-16.
  10. ^ "2024 AAAS Fellows | American Association for the Advancement of Science (AAAS)". www.aaas.org. Retrieved 2025-04-19.
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