Joseph O'Brien

Joseph O'Brien may refer to:

• Joseph Patrick O'Brien (born 1993), Irish jockey and racehorse trainer
• Joseph O'Brien (singer), American singer and songwriter
• Joseph C. O'Brien (born 1965), mayor of Worcester, Massachusetts, USA
• Joseph J. O'Brien (1897–1953), U.S. congressman from New York
• Joseph Leonard O'Brien (1895–1973), lieutenant governor of New Brunswick
• Joseph O'Brien (rower), Australian rower
• Joe O'Brien (basketball) (born 1955), basketball player
• Joe O'Brien (footballer) (1875 – after 1906), Scottish football full back
• Joey O'Brien (born 1986), Irish international and former Bolton Wanderers footballer