IFNA4

IFNA4
Identifiers
Aliases	IFNA4, IFN-alpha4a, INFA4, interferon, alpha 4, interferon alpha 4
External IDs	OMIM: 147564; MGI: 3649260; HomoloGene: 68536; GeneCards: IFNA4; OMA:IFNA4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,187,671 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	88,595,161 bp
RNA expression pattern
	Top expressed in
	aorta; ; thoracic aorta; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; type I interferon receptor binding; protein binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	defense response; adaptive immune response; response to exogenous dsRNA; response to virus; blood coagulation; positive regulation of peptidyl-serine phosphorylation of STAT protein; natural killer cell activation involved in immune response; B cell proliferation; humoral immune response; defense response to virus; type I interferon signaling pathway; B cell differentiation; T cell activation involved in immune response; cytokine-mediated signaling pathway; innate immune response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3441
	230398
	ENSG00000236637
	ENSMUSG00000078355
	P05014
	Q810G1
	NM_021068
	NM_206867
	NP_066546
	NP_996750
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000236637 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA4 interferon, alpha 4".

Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules". DNA. 4 (3): 221–32. doi:10.1089/dna.1985.4.221. PMID 3891272.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Linnane AW, Beilharz MW, McMullen GL, et al. (1984). "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides". Biochem. Int. 8 (5): 725–32. PMID 6089830.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Hussain M, Gill DS, Liao MJ (1997). "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population". J. Interferon Cytokine Res. 17 (9): 559–66. doi:10.1089/jir.1997.17.559. PMID 9335434.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yokota S, Yokosawa N, Okabayashi T, et al. (2004). "Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway". J. Virol. 78 (12): 6282–6. doi:10.1128/JVI.78.12.6282-6286.2004. PMC 416529. PMID 15163721.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000236637 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385305-5] Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

[entrez-6] "Entrez Gene: IFNA4 interferon, alpha 4".

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References

Further reading