Howard Y. Chang

Howard Y. Chang
張元豪
Born
Taipei, Taiwan
EducationHarvard University (BA, MD)
Massachusetts Institute of Technology (PhD)
FatherChang Chau-hsiung
Scientific career
FieldsMolecular biology
InstitutionsStanford University, Amgen
Doctoral advisorDavid Baltimore
Other academic advisors
Chinese name
Traditional Chinese張元豪
Simplified Chinese张元豪
Transcriptions
Standard Mandarin
Hanyu PinyinZhang Yuan-Hao
Bopomofoㄓㄤ ㄩㄢˊ ㄏㄠˊ
Wade–GilesChang Yuan-Hao

Howard Yuan-Hao Chang (traditional Chinese: 張元豪; born 1972) is a Taiwanese-American physician-scientist and is the senior vice president of research and chief scientific officer of Amgen.[1] He was previously the Virginia and D. K. Ludwig Professor of Cancer Genomics and of Genetics at the Stanford University School of Medicine. He is best known for his research with long non-coding RNAs.[2] a principal investigator at the Howard Hughes Medical Institute,[3]

Biography

Chang was born in Taipei, Taiwan, to a Taiwanese family of physicians.[4] His father, Chang Chau-hsiung, was a Taiwanese physician and politician.[5]

Chang earned a bachelor's degree in biochemistry from Harvard University and completed a Ph.D. in biology at the Massachusetts Institute of Technology (MIT) and earned a Doctor of Medicine (M.D.) at Harvard Medical School as part of the "Harvard-MIT physician scientist training program" working in David Baltimore's laboratory.[6] He did his dermatology residency and postdoctoral training at Stanford with Patrick O. Brown. After starting his own lab, his group discovered unexpected transcriptional activity for noncoding DNA and identified HOTAIR which further confirmed the importance of long non-coding RNAs.[7][8]

Awards

References

  1. ^ "Amgen taps Stanford's Howard Chang to take CSO reins from R&D chief Jay Bradner". Retrieved 21 November 2024.
  2. ^ "Howard Y. Chang, MD PhD". Stanford University Neurosciences Institute.
  3. ^ "Howard Y. Chang, MD, PhD". Howard Hughes Medical Institute. Retrieved January 10, 2020.
  4. ^ "Curriculum Vitae: Howard Y. Chang". Stanford University. Archived from the original on December 5, 2005. Retrieved July 27, 2018.
  5. ^ "中研院院士解開「自體免疫疾病」之謎！張昭雄之子張元豪：罪魁禍首是RNA分子「Xist」". The Storm Media (in Chinese (Taiwan)). 4 February 2024. Retrieved 12 October 2024.
  6. ^ "Howard Y. Chang, MD PhD". Stanford University. Retrieved July 27, 2018.
  7. ^ Rinn, John L.; Kertesz, Michael; Wang, Jordon K.; Squazzo, Sharon L.; Xu, Xiao; Brugmann, Samantha A.; Goodnough, L. Henry; Helms, Jill A.; Farnham, Peggy J.; Segal, Eran; Chang, Howard Y. (June 2007). "Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs". Cell. 129 (7): 1311–1323. doi:10.1016/j.cell.2007.05.022. PMC 2084369.
  8. ^ Ahmed, Farooq (13 April 2021). "Profile of Howard Y. Chang". Proceedings of the National Academy of Sciences. 118 (15). doi:10.1073/pnas.2104246118. PMC 8053961.
  9. ^ "2018 NAS Award in Molecular Biology". National Academy of Sciences. Retrieved January 10, 2020.
  10. ^ "Howard Y. Chang". American Academy of Arts & Sciences. Retrieved 2021-01-09.
  11. ^ King Faisal Prize 2024
  12. ^ "Stanley J. Korsmeyer Award: 2024 Howard Y. Chang". The American Society for Clinical Investigation. 2024-02-15. Retrieved 2025-03-10.
  13. ^ Albany Medical Center Prize 2024
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