HOOK2

HOOK2
Identifiers
Aliases	HOOK2, HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDs	OMIM: 607824; MGI: 2181664; HomoloGene: 8332; GeneCards: HOOK2; OMA:HOOK2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,872,740 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,003,349 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; apex of heart; ; left lobe of thyroid gland; ; body of pancreas; ; anterior pituitary; ; right uterine tube; ; minor salivary glands; ; skin of abdomen; ; mucosa of transverse colon; ; skin of leg;
	Top expressed in
	spermatid; ; yolk sac; ; right kidney; ; proximal tubule; ; intestinal villus; ; spermatocyte; ; jejunum; ; Hindgut; ; seminiferous tubule; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; microtubule binding; dynein light intermediate chain binding;
Cellular component	HOPS complex; cytoplasm; microtubule organizing center; centrosome; microtubule; cytoskeleton; FHF complex; cytosol; intracellular membrane-bounded organelle;
Biological process	protein transport; lysosome organization; early endosome to late endosome transport; endocytosis; endosome organization; endosome to lysosome transport; cytoskeleton-dependent intracellular transport; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	29911
	170833
	ENSG00000095066
	ENSMUSG00000052566
	Q96ED9
	Q7TMK6
	NM_001100176; NM_013312
	NM_001167991; NM_133255; NM_001363497; NM_001363498
	NP_001093646; NP_037444
NP_001161463; NP_573518; NP_001350426; NP_001350427; NP_001359286;
	NP_001359287; NP_001359288; NP_001359289; NP_001359290; NP_001359291
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Hook homolog 2 (HK2) is a protein^[5] that in humans is encoded by the HOOK2 gene.^[6]^[7]

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095066 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052566 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
^ Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
^ ^a ^b "Entrez Gene: hook homolog 2 (Drosophila)".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex". Mol. Biol. Cell. 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC 2592673. PMID 18799622.
Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome". Mol. Biol. Cell. 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC 2777108. PMID 19793914.
Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156. PMID 17540036.
Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function". Traffic. 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400. S2CID 19664393.
Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095066 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052566 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9927460-5] Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.

[pmid11238449-6] Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.

[entrez-7] "Entrez Gene: hook homolog 2 (Drosophila)".

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Function

References

Further reading