HLA-A66

HLA-A66
HLA-A66
(MHC Class I, A cell surface antigen)
	HLA-A66
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*66--, β2-microglobulin
Older names	A10
Subtypes
Subtype
Subtype	allele
A66.1	*6601
A66.2	*6602
{{{cNick3}}}	*66{{{cAllele3}}}
{{{cNick4}}}	*66{{{cAllele4}}}
Rare alleles
Subtype
Subtype	allele
A66.3	*6603
{{{rnick2}}}	*66{{{rallele2}}}
{{{rnick3}}}	*66{{{rallele3}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁶ subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.^[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[2].

Serotype

A66 recognition of some HLA A*66 gene products^[3]
A*66	A66	A10	A26	A34	Sample
allele	%	%	%	%	size (N)
*6601	20	10	61	8	799
*6602	38	10	4	27	205
*6603	32	7	7	18	28

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.

A*6601 Frequencies

HLA A*6601 frequencies
		freq
ref.	Population	(%)
^[4]	Cameroon Sawa	7.7
^[4]	Kenya Luo	6.8
^[4]	Cameroon Sawa	7.7
^[4]	Cameroon Bakola Pygmy	5.8
^[4]	Cameroon Baka Pygmy	5.0
^[4]	Kenya Nandi	5.0
^[4]	Zimbabwe Harare Shona	0.2
^[4]	Cameroon Baka Pygmy	5.0
^[4]	Cameroon Beti	4.6
^[4]	Cameroon Bamileke	4.5
^[4]	India West Bhils	4.0
^[4]	Zimbabwe Harere Shona	3.8
^[4]	Uganda Kampala	3.8
^[4]	India Mumbai Marathas	2.5
^[4]	Cape Verde Northwestern	2.5
^[4]	Czech republic	2.4
^[4]	Morocco Nador Metalsa	2.1
^[4]	Central Portugal	2.0
^[4]	India West Parsis	2.0
^[4]	South African Natal Zulu	2.0
^[4]	Kenya	1.7
^[4]	Tunisia Tunis	1.7
^[4]	Guinea Bissau	1.5
^[4]	Georgia Tbilisi	1.4
^[4]	Zambia Lusaka	1.2
^[4]	Italy Bergamo	1.1
^[4]	Pakistan Karachi Parsi	1.1
^[4]	Oman	0.8
^[4]	Sudanese	0.8
^[4]	Belgium	0.5
^[4]	Southeast France	0.4
^[4]	Mongolia Buriat	0.4
^[4]	Wales	0.2

HLA A*6602 frequencies
		freq
ref.	Population	(%)
^[4]	South African Natal Zulu	1.5
^[4]	Cameroon Yaounde	1.1
^[4]	Cameroon Bamileke	0.6
^[4]	Senegal Niokholo Mandenka	0.5
^[4]	Kenya Nandi	0.4
^[4]	Zimbabwe Harare Shona	0.2
^[4]	Wales	0.03
HLA A*6603 frequencies
		freq
ref.	Population	(%)
^[4]	Cameroon Pygmy Baka	10.0
^[4]	Cameroon Bakola Pygmy	9.0
^[4]	Cameroon Sawa	7.7
^[4]	CAR Mbenzele Pygmy	2.8
^[4]	Zimbabwe Harare Shona	0.2

References

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[pmid8475492-2] Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.

[3] Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid12753660-4] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

[1]

[2]

[3]

[4]