GYKI-32887

GYKI-32887
Clinical data
Other namesGYKI32887; RGH-7825; RGH7825; 8-((N-2-Azidoethyl-N-methylsulfonylamino)methyl)-6-methylergol-8-ene
Drug classDopamine agonist; Antiparkinsonian agent
Identifiers
  • N-[[(6aR,10aR)-7-methyl-6,6a,8,10a-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methyl]-N-(2-azidoethyl)methanesulfonamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC19H24N6O2S
Molar mass400.50 g·mol−1
3D model (JSmol)
  • CN1CC(=C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CN(CCN=[N+]=[N-])S(=O)(=O)C
  • InChI=1S/C19H24N6O2S/c1-24-11-13(12-25(28(2,26)27)7-6-22-23-20)8-16-15-4-3-5-17-19(15)14(10-21-17)9-18(16)24/h3-5,8,10,16,18,21H,6-7,9,11-12H2,1-2H3/t16-,18-/m1/s1
  • Key:KHWYJNRYIAULDT-SJLPKXTDSA-N

GYKI-32887, also known as RGH-7825, is a dopamine agonist and antiparkinsonian agent of the ergoline family which was never marketed.[1][2][3][4] It has a lysergamide-like structure but is not technically a lysergamide itself.[1] Similarly to other D2-like receptor agonists, direct injection of small doses of GYK-32887 into the nucleus accumbens decreases locomotor activity in rodents.[3] This effect can be blocked by D2-like receptor antagonists like haloperidol, fluphenazine, and sulpiride.[3] GYKI-32887 was first described in the scientific literature by 1983.[2][3][4]

See also

References

  1. ^ a b Negwer M (2001). Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. ISBN 978-3-527-30247-5. Retrieved 30 June 2025.
  2. ^ a b Borsy J, Király I, Magó-Karácsony E, Bagdy E, Berzétei I (1983). "Psychopharmacological Effects of a New Dopaminergic Agonist Compound GYK-32887". Acta Pharmaceutica Suecica: 190–194.
  3. ^ a b c d Király I, Van Ree JM (May 1984). "Non-opiate beta-endorphin fragments and dopamine--VI. Behavioural analysis of the interaction between gamma-type endorphins and dopaminergic systems in the nucleus accumbens of rats". Neuropharmacology. 23 (5): 511–516. doi:10.1016/0028-3908(84)90023-6. PMID 6204246.
  4. ^ a b Nógrádi M (1985). "RGH-7825". Drugs of the Future. 10 (9): 753. doi:10.1358/dof.1985.010.09.71741.
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