GSDMB

GSDMB
Identifiers
Aliases	GSDMB, GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1
External IDs	OMIM: 611221; HomoloGene: 88856; GeneCards: GSDMB; OMA:GSDMB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,919,854 bp
RNA expression pattern
	Top expressed in
	rectum; ; right lobe of liver; ; mucosa of transverse colon; ; granulocyte; ; mucosa of ileum; ; duodenum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; jejunal mucosa; ; body of stomach;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function; phosphatidylserine binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane; cellular component;
Biological process	programmed cell death; biological process; pyroptosis;
	Sources:Amigo / QuickGO
Orthologs
	55876
	n/a
	ENSG00000073605
	n/a
	Q8TAX9
	n/a
	NM_001042471; NM_001165958; NM_001165959; NM_018530; NM_001369402
	n/a
	NP_001035936; NP_001159430; NP_001159431; NP_061000; NP_001356331
	n/a
	Wikidata
View/Edit Human

Gasdermin B is a protein that in humans is encoded by the GSDMB gene. ^[3]

Function

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

Clinical significance

GSDMB expression has been linked to higher survival rates for lung cancer patients.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Gasdermin B". Retrieved 2016-08-26.
^ "MCM team has been researching GSDMB". World Community Grid. 12 July 2023. Retrieved 20 September 2024.

Function

Clinical significance

References

Further reading