Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.[5][6].
Structure
It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.[7]
Tissue distribution
GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.[7]
Function
It has been identified as the receptor for the chemokine-like protein CXCL17.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170128 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052759 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Jung BP, Nguyen T, Kolakowski LF Jr, Lynch KR, Heng HH, George SR, et al. (Feb 1997). "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1". Biochemical and Biophysical Research Communications. 230 (1): 69–72. doi:10.1006/bbrc.1996.5828. PMID 9020062.
- ^ "Entrez Gene: GPR25 G protein-coupled receptor 25".
- ^ a b c Ocón B, Xiang M, Bi Y, Tan S, Brulois K, Ayesha A, et al. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. Bibcode:2024Natur.635..736O. doi:10.1038/s41586-024-08043-2. PMC 11887596. PMID 39293486.
Further reading