Grb2 associated binding protein 3

GAB3
Identifiers
Aliases	GAB3, GRB2 associated binding protein 3
External IDs	OMIM: 300482; MGI: 2387324; HomoloGene: 15417; GeneCards: GAB3; OMA:GAB3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,751,583 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	74,129,064 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; granulocyte; ; apex of heart; ; blood; ; spleen; ; monocyte; ; gonad; ; trabecular bone; ; testicle;
	Top expressed in
	zygote; ; granulocyte; ; stroma of bone marrow; ; blood; ; embryo; ; secondary oocyte; ; embryo; ; Rostral migratory stream; ; spleen; ; thymus;
	More reference expression data
	n/a
Orthologs
	139716
	210710
	ENSG00000160219
	ENSMUSG00000032750
	Q8WWW8
	Q8BSM5
	NM_001081573; NM_001282283; NM_080612
	NM_181584
	NP_001075042; NP_001269212; NP_542179
	NP_853615
	Wikidata
View/Edit Human	View/Edit Mouse

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. ^[5]

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032750 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Mol. Cell. Biol. 22 (11): 3744–56. doi:10.1128/mcb.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
Sliz, Anna; Locker, Kathryn C. S.; Lampe, Kristin; Godarova, Alzbeta; Plas, David R.; Janssen, Edith M.; Jones, Helen; Herr, Andrew B.; Hoebe, Kasper (2019). "Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy". Science Immunology. 4 (38): eaav3866. doi:10.1126/sciimmunol.aav3866. ISSN 2470-9468. PMC 7068803. PMID 31375526.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032750 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ncbi-5] "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

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Function

References

Further reading