Daf-14

MH2 domain-containing protein
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-14
Entrez177908
RefSeq (mRNA)NM_001268546.3
RefSeq (Prot)NP_001255475.1
UniProtG5EEP2
Other data
ChromosomeIV: 10.25 - 10.26 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The DAF-14 is a gene of the nematode Caenorhabditis elegans encoding a R-SMAD protein of TGF-beta signaling pathway, which will be phosphorylated and forms a heterodimer with phosphorylated daf-8 when the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4, then the heterodimer enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.[1]

References

  1. ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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