DMPX

DMPX
Clinical data
ATC code
  • None
Identifiers
  • 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.162.258
Chemical and physical data
FormulaC10H10N4O2
Molar mass218.216 g·mol−1
3D model (JSmol)
  • Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
  • InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
  • Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity for A2 adenosine receptors, in contrast to the A1 subtype receptors.[1] DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist NECA. The locomotor stimulation caused by DMPX (ED50 10 μmol/kg) was similarly higher than caffeine.[1]

See also

References

  1. ^ a b Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.
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