DBR1

DBR1
Identifiers
Aliases	DBR1, debranching RNA lariats 1
External IDs	OMIM: 607024; MGI: 1931520; HomoloGene: 9428; GeneCards: DBR1; OMA:DBR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	138,174,921 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	99,466,554 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; tendon of biceps brachii; ; amniotic fluid; ; germinal epithelium; ; gonad; ; epithelium of nasopharynx; ; ganglionic eminence; ; islet of Langerhans; ; ventricular zone;
	Top expressed in
	primitive streak; ; epiblast; ; abdominal wall; ; hair follicle; ; medial ganglionic eminence; ; trigeminal ganglion; ; maxillary prominence; ; motor neuron; ; endothelial cell of lymphatic vessel; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; RNA lariat debranching enzyme activity; hydrolase activity, acting on ester bonds; metal ion binding; RNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; mRNA processing; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	51163
	83703
	ENSG00000138231
	ENSMUSG00000032469
	Q9UK59
	Q923B1
	NM_016216
	NM_031403; NM_001368298
	NP_057300
	NP_113580; NP_001355227
	Wikidata
View/Edit Human	View/Edit Mouse

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.^[5]^[6]

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res. 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720. PMID 10982890.
^ ^a ^b "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".

Chapman KB, Boeke JD (1991). "Isolation and characterization of the gene encoding yeast debranching enzyme". Cell. 65 (3): 483–92. doi:10.1016/0092-8674(91)90466-C. PMID 1850323. S2CID 39225964.
Arenas J, Hurwitz J (1987). "Purification of a RNA debranching activity from HeLa cells". J. Biol. Chem. 262 (9): 4274–9. doi:10.1016/S0021-9258(18)61343-2. PMID 2435736.
Martin A, Schneider S, Schwer B (2002). "Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome". J. Biol. Chem. 277 (20): 17743–50. doi:10.1074/jbc.M200762200. PMID 11886864.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ye Y, De Leon J, Yokoyama N, et al. (2006). "DBR1 siRNA inhibition of HIV-1 replication". Retrovirology. 2: 63. doi:10.1186/1742-4690-2-63. PMC 1266399. PMID 16232320.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138231 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032469 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10982890-5] Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res. 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720. PMID 10982890.

[entrez-6] "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".

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References

Further reading