Cytokine dependent hematopoietic cell linker

CLNK
Identifiers
Aliases	CLNK, MIST, cytokine dependent hematopoietic cell linker
External IDs	OMIM: 611434; MGI: 1351468; HomoloGene: 8450; GeneCards: CLNK; OMA:CLNK - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	10,684,768 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	39,034,155 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; human kidney; ; lymph node; ; renal medulla; ; thymus; ; pharynx; ; corpus epididymis; ; epithelium of nasopharynx; ; cecum; ; gonad;
	Top expressed in
	embryo; ; embryo; ; spermatid; ; blastocyst; ; right kidney; ; gastrula; ; duodenum; ; jejunum; ; spermatocyte; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	intracellular anatomical structure;
Biological process	intracellular signal transduction; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	116449
	27278
	ENSG00000109684
	ENSMUSG00000039315
	Q7Z7G1
	Q9QZE2
	NM_052964
	NM_013748
	NP_443196
	NP_038776
	Wikidata
View/Edit Human	View/Edit Mouse

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. ^[5]

Function

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109684 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039315 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.

Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009). "Screening for replication of genome-wide SNP associations in sporadic ALS". Eur. J. Hum. Genet. 17 (2): 213–8. doi:10.1038/ejhg.2008.194. PMC 2986065. PMID 18987618.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID 25591661. S2CID 23426576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109684 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039315 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cytokine dependent hematopoietic cell linker". Retrieved 2017-09-06.

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Function

References

Further reading