Cerebral dopamine neurotrophic factor also known as ARMET-like protein 1 is a protein that in humans is encoded by the CDNF gene.[5][6]
In preclinical models, localized injections of CDNF prevent and restore 6-OHDA induced dopaminergic lesions.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000185267 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039496 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Cerebral dopamine neurotrophic factor".
- ^ a b Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, et al. (Jul 2007). "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo". Nature. 448 (7149): 73–7. Bibcode:2007Natur.448...73L. doi:10.1038/nature05957. PMID 17611540. S2CID 4409832.
Further reading
- Choi JM, Hong JH, Chae MJ, Ngyuen PH, Kang HS, Ma HI, et al. (Apr 2011). "Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease". Neuroscience Letters. 493 (3): 97–101. doi:10.1016/j.neulet.2011.02.013. PMID 21320571. S2CID 207133072.
- Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, et al. (Dec 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
- Lohoff FW, Bloch PJ, Ferraro TN, Berrettini WH, Pettinati HM, Dackis CA, et al. (Apr 2009). "Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence". Neuroscience Letters. 453 (3): 199–203. doi:10.1016/j.neulet.2009.02.026. PMC 2680755. PMID 19429035.
- Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, et al. (Apr 2009). "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional". Protein Engineering, Design & Selection. 22 (4): 233–41. doi:10.1093/protein/gzn080. PMID 19258449.
External links
- Overview of all the structural information available in the PDB for UniProt: Q49AH0 (Cerebral dopamine neurotrophic factor) at the PDBe-KB.