CHAMP1

CHAMP1
Identifiers
Aliases	CHAMP1, C13orf8, CAMP, CHAMP, ZNF828, MRD40, chromosome alignment maintaining phosphoprotein 1
External IDs	OMIM: 616327; MGI: 1196398; HomoloGene: 18780; GeneCards: CHAMP1; OMA:CHAMP1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	114,337,626 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,931,639 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; secondary oocyte; ; ganglionic eminence; ; epithelium of colon; ; tibialis anterior muscle; ; cardiac muscle tissue of right atrium; ; thymus; ; skin of thigh; ; myocardium of left ventricle; ; stromal cell of endometrium;
	Top expressed in
	hand; ; zygote; ; oocyte; ; secondary oocyte; ; primary oocyte; ; otolith organ; ; utricle; ; maxillary prominence; ; epiblast; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; nucleic acid binding;
Cellular component	cytoplasm; chromosome; spindle; chromosome, centromeric region; cytoskeleton; condensed chromosome; nucleus; kinetochore; nucleoplasm; Flemming body;
Biological process	sister chromatid biorientation; protein localization to microtubule; attachment of mitotic spindle microtubules to kinetochore; protein localization to kinetochore;
	Sources:Amigo / QuickGO
Orthologs
	283489
	101994
	ENSG00000198824
	ENSMUSG00000047710
	Q96JM3
	Q8K327
	NM_032436; NM_001164144; NM_001164145
	NM_181854; NM_001363455
	NP_001157616; NP_001157617; NP_115812
	NP_862902; NP_001350384
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome alignment-maintaining phosphoprotein 1 (CHAMP1) also known as zinc finger protein 828 (ZNF828) is a protein that in humans is encoded by the CHAMP1 gene.^[5] CHAMP1 is a key component of a protein complex that has a role in facilitating homology-directed repair of DNA.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: C13orf8 chromosome 13 open reading frame 8".
^ Li F, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, Mukkavalli S, Greenberg RA, D'Andrea AD (February 2025). "CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair". Nat Commun. 16 (1): 1714. doi:10.1038/s41467-025-56834-6. PMC 11832927. PMID 39962076.

External links

CHAMP1 UK - Charity for those affected by CHAMP1 disorders.
CHAMP1 Research Foundation - Non-Profit raising funds for research into CHAMP1 and CHAMP1 disorders.
Human CAMP genome location and CAMP gene details page in the UCSC Genome Browser.
Human CHAMP1 genome location and CHAMP1 gene details page in the UCSC Genome Browser.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047710 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C13orf8 chromosome 13 open reading frame 8".

[Li2025-6] Li F, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, Mukkavalli S, Greenberg RA, D'Andrea AD (February 2025). "CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair". Nat Commun. 16 (1): 1714. doi:10.1038/s41467-025-56834-6. PMC 11832927. PMID 39962076.

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References

External links

Further reading