C1orf38

THEMIS2
Identifiers
Aliases	THEMIS2, C1orf38, ICB-1, thymocyte selection associated family member 2, ICB1, Chromosome 1 open reading frame 38
External IDs	OMIM: 617856; MGI: 2446213; HomoloGene: 21009; GeneCards: THEMIS2; OMA:THEMIS2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,886,685 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,523,698 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; bone marrow cells; ; right lung; ; upper lobe of left lung; ; appendix; ; C1 segment; ; gallbladder;
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; mesenteric lymph nodes; ; blood; ; stroma of bone marrow; ; gastrula; ; subcutaneous adipose tissue; ; submandibular gland; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytoplasm;
Biological process	inflammatory response; immune system process; cell adhesion; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9473
	230787
	ENSG00000130775
	ENSMUSG00000037731
	Q5TEJ8
	Q91YX0
	NM_001039477; NM_001105556; NM_001286113; NM_001286115; NM_004848
	NM_001033308
	NP_001034566; NP_001099026; NP_001273042; NP_001273044; NP_004839
	NP_001028480
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene.^[5] The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712.^[5] C1orf38 has been associated with cancer susceptibility.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130775 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037731 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Chromosome 1 open reading frame 38". Retrieved 2011-12-07.
^ Springwald A, Lattrich C, Seitz S, Ortmann O, Treeck O (July 2009). "Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility". Cancer Investigation. 27 (6): 669–672. doi:10.1080/07357900802620877. PMID 19308812. S2CID 205570175.

Haselberger M, Springwald A, Konwisorz A, Lattrich C, Goerse R, Ortmann O, et al. (July 2011). "Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine. 28 (1): 121–127. doi:10.3892/ijmm.2011.663. PMID 21455565.
Springwald A, Lattrich C, Skrzypczak M, Goerse R, Ortmann O, Treeck O (November 2010). "Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression". Cancer Investigation. 28 (9): 904–909. doi:10.3109/07357907.2010.483511. PMID 20569072. S2CID 35017943.
Konwisorz A, Springwald A, Haselberger M, Goerse R, Ortmann O, Treeck O (March 2010). "Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells". Endocrine-Related Cancer. 17 (1): 147–157. doi:10.1677/ERC-09-0095. PMID 19942713.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130775 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037731 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Chromosome 1 open reading frame 38". Retrieved 2011-12-07.

[6] Springwald A, Lattrich C, Seitz S, Ortmann O, Treeck O (July 2009). "Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility". Cancer Investigation. 27 (6): 669–672. doi:10.1080/07357900802620877. PMID 19308812. S2CID 205570175.

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References

Further reading