Bill Spence

Bill Spence may refer to:

• Bill Spence (footballer) (1929–1993), English footballer
• Bill Spence (musician) (1940–2019), American hammered dulcimer player
• Bill Spence (racing driver) (1906–1929), American racecar driver
• Bill Spence (writer) (1923–2024), English writer

• Billy Spence (died 1980), Northern Ireland activist
• William Spence (disambiguation)