ARHGAP25

ARHGAP25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V89
Identifiers
Aliases	ARHGAP25, HEL-S-308, KAIA0053, Rho GTPase activating protein 25
External IDs	OMIM: 610587; MGI: 2443687; HomoloGene: 45507; GeneCards: ARHGAP25; OMA:ARHGAP25 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	68,826,833 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,510,241 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; monocyte; ; bone marrow cells; ; appendix; ; periodontal fiber; ; tonsil; ; epithelium of colon;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; thymus; ; bone marrow; ; blood; ; lumbar spinal ganglion; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; middle ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	cytosol; phagocytic cup;
Biological process	positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; phagocytosis, engulfment; actin filament organization; negative regulation of small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9938
	232201
	ENSG00000163219
	ENSMUSG00000030047
	P42331
	Q8BYW1
NM_001007231; NM_001166276; NM_001166277; NM_014882; NM_001364819;
	NM_001364820; NM_001364821
	NM_001037727; NM_001286610; NM_175476
NP_001007232; NP_001159748; NP_001159749; NP_055697; NP_001351748;
	NP_001351749; NP_001351750
	NP_001032816; NP_001273539; NP_780685
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene.^[5] The gene is also known as KAIA0053.^[5] ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Rho GTPase activating protein 25". Retrieved 2011-12-05.
^ Katoh M, Katoh M (August 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.

Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K (January 2010). "Mutation of ARHGAP9 in patients with coronary spastic angina". Journal of Human Genetics. 55 (1): 42–9. doi:10.1038/jhg.2009.120. PMID 19911011.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030047 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Rho GTPase activating protein 25". Retrieved 2011-12-05.

[6] Katoh M, Katoh M (August 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.

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References

Further reading