AKO-001

AKO-001
Combination of
DimethyltryptamineSerotonergic psychedelic
? ComponentUndisclosed specific plant bioactive
Clinical data
Other namesAKO001; Dimethyltryptamine/specific plant bioactive; DMT/specific plant bioactive

AKO-001, or AKO001, is a combination of the non-selective serotonin receptor agonist and serotonergic psychedelic dimethyltryptamine (DMT) and an undisclosed "specific plant bioactive" which is under development for the treatment of stroke.[1][2][3] While the "specific plant bioactive" in the combination and the action of this compound have not been disclosed, certain plant compounds, such as the β-carboline harmine in Banisteriopsis caapi, are reversible monoamine oxidase A (MAO-A) inhibitors and inhibit the metabolism of DMT, in turn greatly potentiating DMT and allowing it to become orally active.[4][5][6] AKO-001 is being developed by Akome Biotech.[1][2][3] As of March 2022, the drug is in the preclinical research stage of development.[1][2][3]

See also

References

  1. ^ a b c "AKO 001". AdisInsight. 8 March 2022. Retrieved 15 February 2025.
  2. ^ a b c "Delving into the Latest Updates on AKO-001 with Synapse". Synapse. 23 January 2025. Retrieved 15 February 2025.
  3. ^ a b c "AKO-001 Drug Profile". Ozmosi. 2 September 2022. Retrieved 16 February 2025.
  4. ^ Dos Santos RG, Hallak JE (November 2024). "Ayahuasca: pharmacology, safety, and therapeutic effects". CNS Spectrums: 1–9. doi:10.1017/S109285292400213X. PMID 39564645.
  5. ^ Egger K, Aicher HD, Cumming P, Scheidegger M (September 2024). "Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors". Cellular and Molecular Life Sciences. 81 (1): 395. doi:10.1007/s00018-024-05353-6. PMC 11387584. PMID 39254764.
  6. ^ Berlowitz I, Egger K, Cumming P (2022). "Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca". Frontiers in Pharmacology. 13: 886408. doi:10.3389/fphar.2022.886408. PMC 9121195. PMID 35600851.
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